Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
NOTCH1
mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting
NOTCH1
mutations drive clonal expansion but impede carcinogenesis. Here we test this hypothesis. Sequencing
NOTCH1
mutant clones in aging human esophagus reveals frequent biallelic mutations th...
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Full title
Notch1 mutations drive clonal expansion in normal esophageal epithelium but impair tumor growth
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9925379
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9925379
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/s41588-022-01280-z
