Dissecting cell identity via network inference and in silico gene perturbation
Dissecting cell identity via network inference and in silico gene perturbation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Cell identity is governed by the complex regulation of gene expression, represented as gene-regulatory networks
1
. Here we use gene-regulatory networks inferred from single-cell multi-omics data to perform in silico transcription factor perturbations, simulating the consequent changes in cell identity using only unperturbed wild-type data. W...
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Full title
Dissecting cell identity via network inference and in silico gene perturbation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9946838
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9946838
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ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-05688-9
