The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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The 5-hydroxymethylcytosine binding, embryonic stem-cell-specific (HMCES) protein forms a covalent DNA-protein cross-link (DPC) with abasic (AP) sites in single-stranded DNA, and the resulting HMCES-DPC is thought to suppress double-strand break formation in S phase. However, the dynamics of HMCES cross-linking and whether any DNA repair pathways n...
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Full title
The HMCES DNA-protein cross-link functions as an intermediate in DNA interstrand cross-link repair
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9949344
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9949344
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-022-00764-0
