Self-supervised machine learning pushes the sensitivity limit in label-free detection of single prot...
Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa
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Publisher
New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
Interferometric scattering (iSCAT) microscopy is a label-free optical method capable of detecting single proteins, localizing their binding positions with nanometer precision, and measuring their mass. In the ideal case, iSCAT is limited by shot noise such that collection of more photons should extend its detection sensitivity to biomolecules of ar...
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Full title
Self-supervised machine learning pushes the sensitivity limit in label-free detection of single proteins below 10 kDa
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9998267
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9998267
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ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-023-01778-2
