A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroe...
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors
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Full title
Author / Creator
Alvarez, Mariano J. , Subramaniam, Prem S. , Tang, Laura H. , Grunn, Adina , Aburi, Mahalaxmi , Rieckhof, Gabrielle , Komissarova, Elena V. , Hagan, Elizabeth A. , Bodei, Lisa , Clemons, Paul A. , Dela Cruz, Filemon S. , Dhall, Deepti , Diolaiti, Daniel , Fraker, Douglas A. , Ghavami, Afshin , Kaemmerer, Daniel , Karan, Charles , Kidd, Mark , Kim, Kyoung M. , Kim, Hee C. , Kunju, Lakshmi P. , Langel, Ülo , Li, Zhong , Lee, Jeeyun , Li, Hai , LiVolsi, Virginia , Pfragner, Roswitha , Rainey, Allison R. , Realubit, Ronald B. , Remotti, Helen , Regberg, Jakob , Roses, Robert , Rustgi, Anil , Sepulveda, Antonia R. , Serra, Stefano , Shi, Chanjuan , Yuan, Xiaopu , Barberis, Massimo , Bergamaschi, Roberto , Chinnaiyan, Arul M. , Detre, Tony , Ezzat, Shereen , Frilling, Andrea , Hommann, Merten , Jaeger, Dirk , Kim, Michelle K. , Knudsen, Beatrice S. , Kung, Andrew L. , Leahy, Emer , Metz, David C. , Milsom, Jeffrey W. , Park, Young S. , Reidy-Lagunes, Diane , Schreiber, Stuart , Washington, Kay , Wiedenmann, Bertram , Modlin, Irvin and Califano, Andrea
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
We introduce and validate a new precision oncology framework for the systematic prioritization of drugs targeting mechanistic tumor dependencies in individual patients. Compounds are prioritized on the basis of their ability to invert the concerted activity of master regulator proteins that mechanistically regulate tumor cell state, as assessed fro...
Alternative Titles
Full title
A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors
Authors, Artists and Contributors
Author / Creator
Subramaniam, Prem S.
Tang, Laura H.
Grunn, Adina
Aburi, Mahalaxmi
Rieckhof, Gabrielle
Komissarova, Elena V.
Hagan, Elizabeth A.
Bodei, Lisa
Clemons, Paul A.
Dela Cruz, Filemon S.
Dhall, Deepti
Diolaiti, Daniel
Fraker, Douglas A.
Ghavami, Afshin
Kaemmerer, Daniel
Karan, Charles
Kidd, Mark
Kim, Kyoung M.
Kim, Hee C.
Kunju, Lakshmi P.
Langel, Ülo
Li, Zhong
Lee, Jeeyun
Li, Hai
LiVolsi, Virginia
Pfragner, Roswitha
Rainey, Allison R.
Realubit, Ronald B.
Remotti, Helen
Regberg, Jakob
Roses, Robert
Rustgi, Anil
Sepulveda, Antonia R.
Serra, Stefano
Shi, Chanjuan
Yuan, Xiaopu
Barberis, Massimo
Bergamaschi, Roberto
Chinnaiyan, Arul M.
Detre, Tony
Ezzat, Shereen
Frilling, Andrea
Hommann, Merten
Jaeger, Dirk
Kim, Michelle K.
Knudsen, Beatrice S.
Kung, Andrew L.
Leahy, Emer
Metz, David C.
Milsom, Jeffrey W.
Park, Young S.
Reidy-Lagunes, Diane
Schreiber, Stuart
Washington, Kay
Wiedenmann, Bertram
Modlin, Irvin
Califano, Andrea
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_su_158352
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_su_158352
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0138-4
