Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models
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Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Progranulin overexpression in Alzheimer's disease model mice protects against neuronal loss and enhances cognitive deficits.
Haploinsufficiency of the progranulin (PGRN) gene (
GRN
) causes familial frontotemporal lobar degeneration (FTLD) and modulates an innate immune response in humans and in mouse models.
GRN
polymorphism may be...
Alternative Titles
Full title
Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models
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TN_cdi_swepub_primary_oai_DiVA_org_su_160586
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_su_160586
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/nm.3672
