Structural basis for ligand binding to an enzyme by a conformational selection pathway
Structural basis for ligand binding to an enzyme by a conformational selection pathway
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Proteins can bind target molecules through either induced fit or conformational selection pathways. In the conformational selection model, a protein samples a scarcely populated high-energy state that resembles a target-bound conformation. In enzymatic catalysis, such high-energy states have been identified as crucial entities for activity and the...
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Full title
Structural basis for ligand binding to an enzyme by a conformational selection pathway
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TN_cdi_swepub_primary_oai_DiVA_org_umu_137382
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_umu_137382
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ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1700919114
