Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance
Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Contents
Many antibiotics inhibit bacterial growth by binding to the ribosome and interfering with protein biosynthesis. Macrolides represent one of the most successful classes of ribosome-targeting antibiotics. The main clinically relevant mechanism of resistance to macrolides is dimethylation of the 23S rRNA nucleotide A2058, located in the drug-binding s...
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Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance
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TN_cdi_swepub_primary_oai_DiVA_org_umu_180216
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_umu_180216
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ISSN
1552-4450,1552-4469
E-ISSN
1552-4469
DOI
10.1038/s41589-020-00715-0
