Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in...
Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
About this item
Full title
Author / Creator
Treusch, Sebastian , Hamamichi, Shusei , Goodman, Jessica L. , Matlack, Kent E. S. , Chung, Chee Yeun , Baru, Valeriya , Shulman, Joshua M. , Parrado, Antonio , Bevis, Brooke J. , Valastyan, Julie S. , Han, Haesun , Lindhagen-Persson, Malin , Reiman, Eric M. , Evans, Denis A. , Bennett, David A. , Olofsson, Anders , Dejager, Philip L. , Tanzi, Rudolph E. , Caldwell, Kim A. , Caldwell, Guy A. and Lindquist, Susan
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Aβ (beta-amyloid peptide) is an important contributor to Alzheimer's disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified the yeast homolog of phosphatidylinositol binding clathrin assembly protein (PICALM) and other endocytic factors connected to AD...
Alternative Titles
Full title
Functional Links Between Aβ Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast
Authors, Artists and Contributors
Author / Creator
Hamamichi, Shusei
Goodman, Jessica L.
Matlack, Kent E. S.
Chung, Chee Yeun
Baru, Valeriya
Shulman, Joshua M.
Parrado, Antonio
Bevis, Brooke J.
Valastyan, Julie S.
Han, Haesun
Lindhagen-Persson, Malin
Reiman, Eric M.
Evans, Denis A.
Bennett, David A.
Olofsson, Anders
Dejager, Philip L.
Tanzi, Rudolph E.
Caldwell, Kim A.
Caldwell, Guy A.
Lindquist, Susan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_umu_50077
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_umu_50077
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1213210