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Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predic...

Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predic...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_151828

Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility

About this item

Full title

Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility

Publisher

Boston: Springer US

Journal title

Pharmaceutical research, 2010-10, Vol.27 (10), p.2187-2196

Language

English

Formats

Publication information

Publisher

Boston: Springer US

More information

Scope and Contents

Contents

ABSTRACT
Purpose
To develop media simulating human colonic fluids (HCFs), to evaluate their use in predicting intracolonic solubility of ketoconazole, danazol and felodipine and to compare solubilities in HCFs with previously determined solubilities in gastric (HGFs) and small intestinal (HIFs) fluids.
Methods
Fasted state simulated col...

Alternative Titles

Full title

Biorelevant Media to Simulate Fluids in the Ascending Colon of Humans and Their Usefulness in Predicting Intracolonic Drug Solubility

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_DiVA_org_uu_151828

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_151828

Other Identifiers

ISSN

0724-8741,1573-904X

E-ISSN

1573-904X

DOI

10.1007/s11095-010-0223-6