KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regula...
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
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Author / Creator
Schumann, Gunter , Liu, Chunyu , O’Reilly, Paul , Gao, He , Song, Parkyong , Xu, Bing , Jia, Tianye , Preis, Sarah , Lepe, Marcelo Segura , Akira, Shizuo , Barbieri, Caterina , Cauchi, Stephane , Clarke, Toni-Kim , Enroth, Stefan , Fische, Kristar , Harris, Sarah E. , Hofer, Edith , Hottenga, Jouke-Jan , Joshi, Peter K. , Kaartinen, Niina , Lemaitre, Rozenn , Luan, Jian’an , Lyytikäinen, Leo-Pekka , Manichaikul, Ani , Mbarek, Hamdi , Milaneschi, Yuri , Moayyeri, Alireza , Mukamal, Kenneth , Nelson, Christopher , Nettleton, Jennifer , Partinen, Eemil , Rawal, Rajesh , Robino, Antonietta , Rose, Lynda , Sala, Cinzia , Scott, Robert , Smith, Albert Vernon , Starr, John M. , Teumer, Alexander , Trompet, Stella , Uitterlinden, André G. , Venturini, Cristina , Vergnaud, Anne-Claire , Verweij, Niek , Vitart, Veronique , Vuckovic, Dragana , Wedenoja, Juho , Yengo, Loic , Yu, Bing , Zhang, Weihua , Boomsma, Dorret I. , Chambers, John , Chasman, Daniel I. , Daniela, Toniolo , Deary, Ian , Eriksson, Johan G. , Esko, Tõnu , Eulenburg, Volker , Froguel, Philippe , Gieger, Christian , Grabe, Hans J. , Gudnason, Vilmundur , Harris, Tamara B. , Hartikainen, Anna-Liisa , Heath, Andrew C. , Hocking, Lynne , Hofman, Albert , Jarvelin, Marjo-Riitta , Jukema, J. Wouter , Kaprio, Jaakko , Kooner, Jaspal S. , Kutalik, Zoltan , Liu, Yongmei , Madden, Pamela A. F. , Morrison, Alanna , Pirastu, Nicola , Psaty, Bruce , Raitakari, Olli , Ridker, Paul , Samani, Nilesh J. , Schmidt, Helena , Spector, Tim D. , Strachan, David , Tzoulaki, Ioanna , van Duijn, Cornelia M. , Marques-Vidal, Pedro , Vollenweider, Peter , Wareham, Nicholas J. , Whitfield, John B. , Wilson, James , Wolffenbuttel, Bruce , Bakalkin, Georgy , Evangelou, Evangelos , Liu, Yun , Rice, Kenneth M. , Desrivières, Sylvane , Kliewer, Steven A. , Mangelsdorf, David J. , Müller, Christian P. and Elliott, Paul
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a genome-wide association metaanalysis and replication study among >105,000 individuals of European ancestry and identified β-Klotho (...
Alternative Titles
Full title
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Authors, Artists and Contributors
Author / Creator
Liu, Chunyu
O’Reilly, Paul
Gao, He
Song, Parkyong
Xu, Bing
Jia, Tianye
Preis, Sarah
Lepe, Marcelo Segura
Akira, Shizuo
Barbieri, Caterina
Cauchi, Stephane
Clarke, Toni-Kim
Enroth, Stefan
Fische, Kristar
Harris, Sarah E.
Hofer, Edith
Hottenga, Jouke-Jan
Joshi, Peter K.
Kaartinen, Niina
Lemaitre, Rozenn
Luan, Jian’an
Lyytikäinen, Leo-Pekka
Manichaikul, Ani
Mbarek, Hamdi
Milaneschi, Yuri
Moayyeri, Alireza
Mukamal, Kenneth
Nelson, Christopher
Nettleton, Jennifer
Partinen, Eemil
Rawal, Rajesh
Robino, Antonietta
Rose, Lynda
Sala, Cinzia
Scott, Robert
Smith, Albert Vernon
Starr, John M.
Teumer, Alexander
Trompet, Stella
Uitterlinden, André G.
Venturini, Cristina
Vergnaud, Anne-Claire
Verweij, Niek
Vitart, Veronique
Vuckovic, Dragana
Wedenoja, Juho
Yengo, Loic
Yu, Bing
Zhang, Weihua
Boomsma, Dorret I.
Chambers, John
Chasman, Daniel I.
Daniela, Toniolo
Deary, Ian
Eriksson, Johan G.
Esko, Tõnu
Eulenburg, Volker
Froguel, Philippe
Gieger, Christian
Grabe, Hans J.
Gudnason, Vilmundur
Harris, Tamara B.
Hartikainen, Anna-Liisa
Heath, Andrew C.
Hocking, Lynne
Hofman, Albert
Jarvelin, Marjo-Riitta
Jukema, J. Wouter
Kaprio, Jaakko
Kooner, Jaspal S.
Kutalik, Zoltan
Liu, Yongmei
Madden, Pamela A. F.
Morrison, Alanna
Pirastu, Nicola
Psaty, Bruce
Raitakari, Olli
Ridker, Paul
Samani, Nilesh J.
Schmidt, Helena
Spector, Tim D.
Strachan, David
Tzoulaki, Ioanna
van Duijn, Cornelia M.
Marques-Vidal, Pedro
Vollenweider, Peter
Wareham, Nicholas J.
Whitfield, John B.
Wilson, James
Wolffenbuttel, Bruce
Bakalkin, Georgy
Evangelou, Evangelos
Liu, Yun
Rice, Kenneth M.
Desrivières, Sylvane
Kliewer, Steven A.
Mangelsdorf, David J.
Müller, Christian P.
Elliott, Paul
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_uu_312625
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_312625
Other Identifiers
ISSN
0027-8424,1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1611243113
