Dual modulation of MCL-1 and mTOR determines the response to sunitinib
Dual modulation of MCL-1 and mTOR determines the response to sunitinib
About this item
Full title
Author / Creator
Elgendy, Mohamed , Abdel-Aziz, Amal Kamal , Renne, Salvatore Lorenzo , Bornaghi, Viviana , Procopio, Giuseppe , Colecchia, Maurizio , Kanesvaran, Ravindran , Toh, Chee Keong , Bossi, Daniela , Pallavicini, Isabella , Perez-Gracia, Jose Luis , Lozano, Maria Dolores , Giandomenico, Valeria , Mercurio, Ciro , Lanfrancone, Luisa , Fazio, Nicola , Nole, Franco , Teh, Bin Tean , Renne, Giuseppe and Minucci, Saverio
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Most patients who initially respond to treatment with the multi-tyrosine kinase inhibitor sunitinib eventually relapse. Therefore, developing a deeper understanding of the contribution of sunitinib's numerous targets to the clinical response or to resistance is crucial. Here, we have shown that cancer cells respond to clinically relevant doses of s...
Alternative Titles
Full title
Dual modulation of MCL-1 and mTOR determines the response to sunitinib
Authors, Artists and Contributors
Author / Creator
Abdel-Aziz, Amal Kamal
Renne, Salvatore Lorenzo
Bornaghi, Viviana
Procopio, Giuseppe
Colecchia, Maurizio
Kanesvaran, Ravindran
Toh, Chee Keong
Bossi, Daniela
Pallavicini, Isabella
Perez-Gracia, Jose Luis
Lozano, Maria Dolores
Giandomenico, Valeria
Mercurio, Ciro
Lanfrancone, Luisa
Fazio, Nicola
Nole, Franco
Teh, Bin Tean
Renne, Giuseppe
Minucci, Saverio
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_uu_316415
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_316415
Other Identifiers
ISSN
0021-9738,1558-8238
E-ISSN
1558-8238
DOI
10.1172/JCI84386
