Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults
Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults
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Publisher
Cham: Springer International Publishing
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Language
English
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Publisher
Cham: Springer International Publishing
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Background
The clearance of cytochrome P450 (CYP) 3A substrates is reported to be reduced with lower age, inflammation and obesity. As it is unknown what the overall influence is of these factors in the case of obese adolescents vs. morbidly obese adults, we studied covariates influencing the clearance of the CYP3A substrate midazolam in a combi...
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Full title
Higher Midazolam Clearance in Obese Adolescents Compared with Morbidly Obese Adults
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TN_cdi_swepub_primary_oai_DiVA_org_uu_354103
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_354103
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ISSN
0312-5963,1179-1926
E-ISSN
1179-1926
DOI
10.1007/s40262-017-0579-4
