Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by hepara...
Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Amyloid-β (Aβ) is the main constituent of amyloid deposits in Alzheimer’s disease (AD). The neuropathology is associated with neuroinflammation. Here, we investigated effects of systemic lipopolysaccharide (LPS)-treatment on neuroinflammation and Aβ deposition in AβPP-mice and double-transgenic mice with brain expression of AβPP and heparanase, an...
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Systemic LPS-induced Aβ-solubilization and clearance in AβPP-transgenic mice is diminished by heparanase overexpression
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TN_cdi_swepub_primary_oai_DiVA_org_uu_380445
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_380445
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ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-40999-4
