α-Synuclein strains target distinct brain regions and cell types
α-Synuclein strains target distinct brain regions and cell types
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Author / Creator
Lau, Angus , So, Raphaella W. L. , Lau, Heather H. C. , Sang, Jason C. , Ruiz-Riquelme, Alejandro , Fleck, Shelaine C. , Stuart, Erica , Menon, Sindhu , Visanji, Naomi P. , Meisl, Georg , Faidi, Rania , Marano, Maria M. , Schmitt-Ulms, Cian , Wang, Zhilan , Fraser, Paul E. , Tandon, Anurag , Hyman, Bradley T. , Wille, Holger , Ingelsson, Martin , Klenerman, David and Watts, Joel C.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
The clinical and pathological differences between synucleinopathies such as Parkinson’s disease and multiple system atrophy have been postulated to stem from unique strains of α-synuclein aggregates, akin to what occurs in prion diseases. Here we demonstrate that inoculation of transgenic mice with different strains of recombinant or brain-derived...
Alternative Titles
Full title
α-Synuclein strains target distinct brain regions and cell types
Authors, Artists and Contributors
Author / Creator
So, Raphaella W. L.
Lau, Heather H. C.
Sang, Jason C.
Ruiz-Riquelme, Alejandro
Fleck, Shelaine C.
Stuart, Erica
Menon, Sindhu
Visanji, Naomi P.
Meisl, Georg
Faidi, Rania
Marano, Maria M.
Schmitt-Ulms, Cian
Wang, Zhilan
Fraser, Paul E.
Tandon, Anurag
Hyman, Bradley T.
Wille, Holger
Ingelsson, Martin
Klenerman, David
Watts, Joel C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_uu_406215
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_406215
Other Identifiers
ISSN
1097-6256,1546-1726
E-ISSN
1546-1726
DOI
10.1038/s41593-019-0541-x
