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Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair re...

Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair re...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_408220

Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents

About this item

Full title

Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

Journal title

Analytical and bioanalytical chemistry, 2020-01, Vol.412 (2), p.299-309

Language

English

Formats

Publication information

Publisher

Berlin/Heidelberg: Springer Berlin Heidelberg

More information

Scope and Contents

Contents

Oligonucleotide drugs represent an emerging area in the pharmaceutical industry. Solid-phase synthesis generates many structurally closely related impurities, making efficient separation systems for purification and analysis a key challenge during pharmaceutical drug development. To increase the fundamental understanding of the important preparativ...

Alternative Titles

Full title

Analytical and preparative separation of phosphorothioated oligonucleotides: columns and ion-pair reagents

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_DiVA_org_uu_408220

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_408220

Other Identifiers

ISSN

1618-2642,1618-2650

E-ISSN

1618-2650

DOI

10.1007/s00216-019-02236-9