BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cel...
BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells
About this item
Full title
BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells
Author / Creator
Journal title
Proceedings of the National Academy of Sciences - PNAS, 2017-07, Vol.114 (29)
Language
English
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Scope and Contents
Contents
The BRAF inhibitors vemurafenib and dabrafenib can be used to treat patients with metastatic melanomas harboring BRAF(V600) mutations. Initial antitumoral responses are often seen, but drug-resistant clones with reactivation of the MEK-ERK pathway soon appear. Recently, the secretome of tumor-derived extracellular vesicles (EVs) has been ascribed i...
Alternative Titles
Full title
BRAF(V600) inhibition alters the microRNA cargo in the vesicular secretome of malignant melanoma cells
Authors, Artists and Contributors
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Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_257733
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_257733
Other Identifiers
ISSN
0027-8424
DOI
10.1073/pnas.1705206114
