G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology invitro and invivo
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology invitro and invivo
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Author / Creator
Simone, Roberto , Balendra, Rubika , Moens, Thomas G , Preza, Elisavet , Wilson, Katherine M , Woodling, Nathan S , Niccoli, Teresa , Gilbert-Jaramillo, Javier , Abdelkarim, Samir , Clayton, Emma L , Clarke, Mica , Konrad, Marie-Therese , Nicoll, Andrew J , Mitchell, Jamie S , Calvo, Andrea , Chio, Adriano , Houlden, Henry , Polke, James M , Ismail, Mohamed A , Stephens, Chad E , Vo, Tam , Farahat, Abdelbasset A , Wilson, W David , Boykin, David W , Zetterberg, Henrik , Partridge, Linda , Wray, Selina , Parkinson, Gary , Neidle, Stephen , Patani, Rickie , Fratta, Pietro and Isaacs, Adrian M
Journal title
Language
English
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Contents
Intronic GGGGCC repeat expansions in C9orf72 are the most common known cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), which are characterised by degeneration of cortical and motor neurons, respectively. Repeat expansions have been proposed to cause disease by both the repeat RNA forming foci that sequester RNA-bindi...
Alternative Titles
Full title
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology invitro and invivo
Authors, Artists and Contributors
Author / Creator
Balendra, Rubika
Moens, Thomas G
Preza, Elisavet
Wilson, Katherine M
Woodling, Nathan S
Niccoli, Teresa
Gilbert-Jaramillo, Javier
Abdelkarim, Samir
Clayton, Emma L
Clarke, Mica
Konrad, Marie-Therese
Nicoll, Andrew J
Mitchell, Jamie S
Calvo, Andrea
Chio, Adriano
Houlden, Henry
Polke, James M
Ismail, Mohamed A
Stephens, Chad E
Vo, Tam
Farahat, Abdelbasset A
Wilson, W David
Boykin, David W
Zetterberg, Henrik
Partridge, Linda
Wray, Selina
Parkinson, Gary
Neidle, Stephen
Patani, Rickie
Fratta, Pietro
Isaacs, Adrian M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_260504
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_260504
Other Identifiers
ISSN
1757-4684
DOI
10.15252/emmm.201707850
