A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies...
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
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Author / Creator
RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia) , IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium) , EADB (Alzheimer Disease European DNA biobank) , Netherlands Brain Bank (NBB) , IPDGC (The International Parkinson Disease Genomics Consortium) , DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank) , GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group , The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group , van der Lee, Sven J. , Conway, Olivia J. , Jansen, Iris , Carrasquillo, Minerva M. , Kleineidam, Luca , van den Akker, Erik , Hernández, Isabel , van Eijk, Kristel R. , Stringa, Najada , Chen, Jason A. , Zettergren, Anna , Andlauer, Till F. M. , Diez-Fairen, Monica , Simon-Sanchez, Javier , Lleó, Alberto , Zetterberg, Henrik , Nygaard, Marianne , Blauwendraat, Cornelis , Savage, Jeanne E. , Mengel-From, Jonas , Moreno-Grau, Sonia , Wagner, Michael , Fortea, Juan , Keogh, Michael J. , Blennow, Kaj , Skoog, Ingmar , Friese, Manuel A. , Pletnikova, Olga , Zulaica, Miren , Lage, Carmen , de Rojas, Itziar , Riedel-Heller, Steffi , Illán-Gala, Ignacio , Wei, Wei , Jeune, Bernard , Orellana, Adelina , Then Bergh, Florian , Wang, Xue , Hulsman, Marc , Beker, Nina , Tesi, Niccolo , Morris, Christopher M. , Indakoetxea, Begoña , Collij, Lyduine E. , Scherer, Martin , Morenas-Rodríguez, Estrella , Ironside, James W. , van Berckel, Bart N. M. , Wiendl, Heinz , Strickland, Samantha L. , Pastor, Pau , Rodríguez Rodríguez, Eloy , Boeve, Bradley F. , Petersen, Ronald C. , Ferman, Tanis J. , van Gerpen, Jay A. , Reinders, Marcel J. T. , Uitti, Ryan J. , Tárraga, Lluís , Maier, Wolfgang , Dols-Icardo, Oriol , Kawalia, Amit , Dalmasso, Maria Carolina , Boada, Mercè , Zettl, Uwe K. , van Schoor, Natasja M. , Beekman, Marian , Allen, Mariet , Masliah, Eliezer , de Munain, Adolfo López , Pantelyat, Alexander , Wszolek, Zbigniew K. , Ross, Owen A. , Dickson, Dennis W. , Graff-Radford, Neill R. , Knopman, David , Rademakers, Rosa , Lemstra, Afina W. , Pijnenburg, Yolande A. L. , Scheltens, Philip , Gasser, Thomas , Chinnery, Patrick F , Hemmer, Bernhard , Huisman, Martijn A. , Troncoso, Juan , Moreno, Fermin , Nohr, Ellen A. , Sørensen, Thorkild I. A. , Heutink, Peter , Sánchez-Juan, Pascual , Posthuma, Danielle , Clarimón, Jordi , Christensen, Kaare , Ertekin-Taner, Nilüfer , Scholz, Sonja W. , Ramirez, Alfredo , Ruiz, Agustín , Slagboom, Eline , van der Flier, Wiesje M. and Holstege, Henne
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
The genetic variant rs72824905-G (minor allele) in the
PLCG2
gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of
PLCG2
in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on...
Alternative Titles
Full title
A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
Authors, Artists and Contributors
Author / Creator
IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium)
EADB (Alzheimer Disease European DNA biobank)
Netherlands Brain Bank (NBB)
IPDGC (The International Parkinson Disease Genomics Consortium)
DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank)
GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group
The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group
van der Lee, Sven J.
Conway, Olivia J.
Jansen, Iris
Carrasquillo, Minerva M.
Kleineidam, Luca
van den Akker, Erik
Hernández, Isabel
van Eijk, Kristel R.
Stringa, Najada
Chen, Jason A.
Zettergren, Anna
Andlauer, Till F. M.
Diez-Fairen, Monica
Simon-Sanchez, Javier
Lleó, Alberto
Zetterberg, Henrik
Nygaard, Marianne
Blauwendraat, Cornelis
Savage, Jeanne E.
Mengel-From, Jonas
Moreno-Grau, Sonia
Wagner, Michael
Fortea, Juan
Keogh, Michael J.
Blennow, Kaj
Skoog, Ingmar
Friese, Manuel A.
Pletnikova, Olga
Zulaica, Miren
Lage, Carmen
de Rojas, Itziar
Riedel-Heller, Steffi
Illán-Gala, Ignacio
Wei, Wei
Jeune, Bernard
Orellana, Adelina
Then Bergh, Florian
Wang, Xue
Hulsman, Marc
Beker, Nina
Tesi, Niccolo
Morris, Christopher M.
Indakoetxea, Begoña
Collij, Lyduine E.
Scherer, Martin
Morenas-Rodríguez, Estrella
Ironside, James W.
van Berckel, Bart N. M.
Wiendl, Heinz
Strickland, Samantha L.
Pastor, Pau
Rodríguez Rodríguez, Eloy
Boeve, Bradley F.
Petersen, Ronald C.
Ferman, Tanis J.
van Gerpen, Jay A.
Reinders, Marcel J. T.
Uitti, Ryan J.
Tárraga, Lluís
Maier, Wolfgang
Dols-Icardo, Oriol
Kawalia, Amit
Dalmasso, Maria Carolina
Boada, Mercè
Zettl, Uwe K.
van Schoor, Natasja M.
Beekman, Marian
Allen, Mariet
Masliah, Eliezer
de Munain, Adolfo López
Pantelyat, Alexander
Wszolek, Zbigniew K.
Ross, Owen A.
Dickson, Dennis W.
Graff-Radford, Neill R.
Knopman, David
Rademakers, Rosa
Lemstra, Afina W.
Pijnenburg, Yolande A. L.
Scheltens, Philip
Gasser, Thomas
Chinnery, Patrick F
Hemmer, Bernhard
Huisman, Martijn A.
Troncoso, Juan
Moreno, Fermin
Nohr, Ellen A.
Sørensen, Thorkild I. A.
Heutink, Peter
Sánchez-Juan, Pascual
Posthuma, Danielle
Clarimón, Jordi
Christensen, Kaare
Ertekin-Taner, Nilüfer
Scholz, Sonja W.
Ramirez, Alfredo
Ruiz, Agustín
Slagboom, Eline
van der Flier, Wiesje M.
Holstege, Henne
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_282901
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_282901
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-019-02026-8
