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Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_301054

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

About this item

Full title

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

Publisher

United States: American Society for Clinical Investigation

Journal title

The Journal of clinical investigation, 2020-12, Vol.130 (12), p.6639-6655

Language

English

Formats

Publication information

Publisher

United States: American Society for Clinical Investigation

More information

Scope and Contents

Contents

By restoring glucose-regulated insulin secretion, glucagon-like peptide-1-based (GLP-1-based) therapies are becoming increasingly important in diabetes care. Normally, the incretins GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) jointly maintain normal blood glucose levels by stimulation of insulin secretion in pancreatic β cells. How...

Alternative Titles

Full title

Gs/Gq signaling switch in β cells defines incretin effectiveness in diabetes

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_gup_ub_gu_se_301054

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_301054

Other Identifiers

ISSN

0021-9738

E-ISSN

1558-8238

DOI

10.1172/JCI140046

How to access this item