Microglial activation and tau propagate jointly across Braak stages
Microglial activation and tau propagate jointly across Braak stages
About this item
Full title
Author / Creator
Pascoal, Tharick A. , Benedet, Andrea L. , Ashton, Nicholas J. , Kang, Min Su , Therriault, Joseph , Chamoun, Mira , Savard, Melissa , Lussier, Firoza Z. , Tissot, Cécile , Karikari, Thomas K. , Ottoy, Julie , Mathotaarachchi, Sulantha , Stevenson, Jenna , Massarweh, Gassan , Schöll, Michael , de Leon, Mony J. , Soucy, Jean-Paul , Edison, Paul , Blennow, Kaj , Zetterberg, Henrik , Gauthier, Serge and Rosa-Neto, Pedro
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Compelling experimental evidence suggests that microglial activation is involved in the spread of tau tangles over the neocortex in Alzheimer’s disease (AD). We tested the hypothesis that the spatial propagation of microglial activation and tau accumulation colocalize in a Braak-like pattern in the living human brain. We studied 130 individuals acr...
Alternative Titles
Full title
Microglial activation and tau propagate jointly across Braak stages
Authors, Artists and Contributors
Author / Creator
Benedet, Andrea L.
Ashton, Nicholas J.
Kang, Min Su
Therriault, Joseph
Chamoun, Mira
Savard, Melissa
Lussier, Firoza Z.
Tissot, Cécile
Karikari, Thomas K.
Ottoy, Julie
Mathotaarachchi, Sulantha
Stevenson, Jenna
Massarweh, Gassan
Schöll, Michael
de Leon, Mony J.
Soucy, Jean-Paul
Edison, Paul
Blennow, Kaj
Zetterberg, Henrik
Gauthier, Serge
Rosa-Neto, Pedro
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_306844
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_306844
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/s41591-021-01456-w
