KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegene...
KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults
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Author / Creator
Driscoll, Ira Frahmand , Lose, Sarah , Ma, Yue , Bendlin, Barbara B. , Gallagher, Catherine , Johnson, Sterling C. , Asthana, Sanjay , Hermann, Bruce , Sager, Mark A. , Blennow, Kaj , Zetterberg, Henrik , Carlsson, Cynthia , Kollmorgen, Gwendlyn , Quijano‐Rubio, Clara , Dubal, Dena and Okonkwo, Ozioma C.
Publisher
United States: John Wiley and Sons Inc
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Language
English
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Publisher
United States: John Wiley and Sons Inc
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Contents
INTRODUCTION
We examined whether the aging suppressor KLOTHO gene's functionally advantageous KL‐VS variant (KL‐VS heterozygosity [KL‐VSHET]) confers resilience against deleterious effects of aging indexed by cerebrospinal fluid (CSF) biomarkers of neuroinflammation (interleukin‐6 [IL‐6], S100 calcium‐binding protein B [S100B], triggering recept...
Alternative Titles
Full title
KLOTHO KL‐VS heterozygosity is associated with diminished age‐related neuroinflammation, neurodegeneration, and synaptic dysfunction in older cognitively unimpaired adults
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Record Identifier
TN_cdi_swepub_primary_oai_gup_ub_gu_se_339654
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_gup_ub_gu_se_339654
Other Identifiers
ISSN
1552-5260,1552-5279
E-ISSN
1552-5279
DOI
10.1002/alz.13912
