SARS-CoV-2 promotes microglial synapse elimination in human brain organoids
SARS-CoV-2 promotes microglial synapse elimination in human brain organoids
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Neuropsychiatric manifestations are common in both the acute and post-acute phase of SARS-CoV-2 infection, but the mechanisms of these effects are unknown. In a newly established brain organoid model with innately developing microglia, we demonstrate that SARS-CoV-2 infection initiate neuronal cell death and cause a loss of post-synaptic termini. D...
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Full title
SARS-CoV-2 promotes microglial synapse elimination in human brain organoids
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TN_cdi_swepub_primary_oai_swepub_ki_se_450409
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_450409
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ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-022-01786-2
