Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
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Author / Creator
Indonesia Schizophrenia Consortium , SynGO Consortium , Psychosis Endophenotypes International Consortium , PsychENCODE , Schizophrenia Working Group of the Psychiatric Genomics Consortium , The SynGO Consortium , Trubetskoy, Vassily , Qi, Ting , Bryois, Julien , Chen, Chia-Yen , Magnusson, Sigurdur , Kim, Minsoo , Adams, Mark , Agartz, Ingrid , Agerbo, Esben , Athanasiu, Lavinia , Bacanu, Silviu A. , Calkins, Monica E. , Carr, Vaughan J. , Consoli, Angèle , Costas, Javier , Davis, Kenneth L. , Degenhardt, Franziska , Dickerson, Faith , Frustaci, Alessandra , Giegling, Ina , Goldstein, Jacqueline I. , González Peñas, Javier , Hayward, Caroline , Howrigan, Daniel P. , Ikeda, Masashi , Kam-Thong, Tony , Kamatani, Yoichiro , Khrunin, Andrey , Kim, Sung-Wan , Klovins, Janis , Kubo, Michiaki , Lazzeroni, Laura C. , Lehrer, Douglas S. , Li, Miaoxin , Liu, Chih-Min , Loughland, Carmel M. , Mallet, Jacques , Mattheisen, Manuel , McCarley, Robert W. , Meier, Sandra , Milani, Lili , Milanova, Vihra , Morley, Christopher P. , Muntané, Gerard , Murphy, Kieran C. , Olincy, Ann , Papadimitriou, George N. , Parellada, Mara , Paunio, Tiina , Pellegrino, Renata , Radant, Allen D. , Saker-Delye, Safaa , Sanjuan, Julio , Savitz, Adam , Seidman, Larry J. , Sim, Kang , Stain, Helen J. , Streit, Fabian , Strengman, Eric , Ta, Thi Minh Tam , Terao, Chikashi , Toncheva, Draga , Veijola, Juha , Waddington, John , Walter, Henrik , Webb, Bradley T. , Wu, Jing Qin , Xu, Zhida , Ayub, Muhammad , Bertolino, Alessandro , Buccola, Nancy G. , Byerley, William F. , Hwu, Hai-Gwo , McCarroll, Steven A. , Neil, Amanda L. , Smoller, Jordan W. , Vilella, Elisabet , Xu, Shuhua , Braff, David , Buxbaum, Joseph D. , Cichon, Sven , Ehrenreich, Hannelore , Escott-Price, Valentina , Esko, Tõnu , Iwata, Nakao , Kirov, George , Lee, Jimmy , Li, Qingqin S. , Malhotra, Anil K. , Malhotra, Dheeraj , McQuillin, Andrew , Morgan, Vera A. , Nöthen, Markus M. , Saka, Meram C. , Sanders, Alan R. , Serretti, Alessandro , van Os, Jim , Yu, Xin , Neale, Benjamin M. and Ripke, Stephan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Schizophrenia has a heritability of 60–80%
1
, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that...
Alternative Titles
Full title
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Authors, Artists and Contributors
Author / Creator
SynGO Consortium
Psychosis Endophenotypes International Consortium
PsychENCODE
Schizophrenia Working Group of the Psychiatric Genomics Consortium
The SynGO Consortium
Trubetskoy, Vassily
Qi, Ting
Bryois, Julien
Chen, Chia-Yen
Magnusson, Sigurdur
Kim, Minsoo
Adams, Mark
Agartz, Ingrid
Agerbo, Esben
Athanasiu, Lavinia
Bacanu, Silviu A.
Calkins, Monica E.
Carr, Vaughan J.
Consoli, Angèle
Costas, Javier
Davis, Kenneth L.
Degenhardt, Franziska
Dickerson, Faith
Frustaci, Alessandra
Giegling, Ina
Goldstein, Jacqueline I.
González Peñas, Javier
Hayward, Caroline
Howrigan, Daniel P.
Ikeda, Masashi
Kam-Thong, Tony
Kamatani, Yoichiro
Khrunin, Andrey
Kim, Sung-Wan
Klovins, Janis
Kubo, Michiaki
Lazzeroni, Laura C.
Lehrer, Douglas S.
Li, Miaoxin
Liu, Chih-Min
Loughland, Carmel M.
Mallet, Jacques
Mattheisen, Manuel
McCarley, Robert W.
Meier, Sandra
Milani, Lili
Milanova, Vihra
Morley, Christopher P.
Muntané, Gerard
Murphy, Kieran C.
Olincy, Ann
Papadimitriou, George N.
Parellada, Mara
Paunio, Tiina
Pellegrino, Renata
Radant, Allen D.
Saker-Delye, Safaa
Sanjuan, Julio
Savitz, Adam
Seidman, Larry J.
Sim, Kang
Stain, Helen J.
Streit, Fabian
Strengman, Eric
Ta, Thi Minh Tam
Terao, Chikashi
Toncheva, Draga
Veijola, Juha
Waddington, John
Walter, Henrik
Webb, Bradley T.
Wu, Jing Qin
Xu, Zhida
Ayub, Muhammad
Bertolino, Alessandro
Buccola, Nancy G.
Byerley, William F.
Hwu, Hai-Gwo
McCarroll, Steven A.
Neil, Amanda L.
Smoller, Jordan W.
Vilella, Elisabet
Xu, Shuhua
Braff, David
Buxbaum, Joseph D.
Cichon, Sven
Ehrenreich, Hannelore
Escott-Price, Valentina
Esko, Tõnu
Iwata, Nakao
Kirov, George
Lee, Jimmy
Li, Qingqin S.
Malhotra, Anil K.
Malhotra, Dheeraj
McQuillin, Andrew
Morgan, Vera A.
Nöthen, Markus M.
Saka, Meram C.
Sanders, Alan R.
Serretti, Alessandro
van Os, Jim
Yu, Xin
Neale, Benjamin M.
Ripke, Stephan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_454204
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_454204
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-04434-5
