Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci...
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
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Author / Creator
Bakker, Mark K. , van Vugt, Joke J. F. A. , Hop, Paul J. , Westra, Harm-Jan , Deelen, Patrick , Hannon, Eilis , Dolzhenko, Egor , Westeneng, Henk-Jan , Tazelaar, Gijs H. P. , van Eijk, Kristel R. , Kooyman, Maarten , Byrne, Ross P. , Doherty, Mark , Heverin, Mark , Al Khleifat, Ahmad , Iacoangeli, Alfredo , Shatunov, Aleksey , Smith, Bradley N. , Chandran, Siddharthan , Pal, Suvankar , Morrison, Karen E. , Shaw, Pamela J. , Hardy, John , Sendtner, Michael , Meyer, Thomas , Başak, Nazli , van der Kooi, Anneke J. , Ratti, Antonia , Fogh, Isabella , Lauria, Giuseppe , Corti, Stefania , Sorarù, Gianni , Filosto, Massimiliano , Chiò, Adriano , Calvo, Andrea , Brunetti, Maura , Nefussy, Beatrice , Osmanovic, Alma , Lerner, Yossef , Gotkine, Marc , Bell, Shaughn , Vourc’h, Patrick , Corcia, Philippe , Salachas, François , Mora Pardina, Jesus S. , Rojas-García, Ricardo , Ross, Jay P. , Weishaupt, Jochen H. , Brenner, David , Bensimon, Gilbert , Payan, Christine A. M. , Saker-Delye, Safa , Wood, Nicholas W. , Rademakers, Rosa , Lieb, Wolfgang , Olsen, Catherine M. , Uitterlinden, Andre G. , Hofman, Albert , Rietschel, Marcella , Traynor, Bryan J. , Mitne Neto, Miguel , Cauchi, Ruben J. , Gaur, Nayana , Ilse, Benjamin , Stubendorff, Beatrice , Witte, Otto W. , Steinbach, Robert , Graff, Caroline , Ataulina, Anastasia , Rogelj, Boris , Koritnik, Blaž , Zidar, Janez , Ravnik-Glavač, Metka , Glavač, Damjan , Stević, Zorica , Drory, Vivian , Povedano, Monica , Blair, Ian P. , Kiernan, Matthew C. , Furlong, Sarah , Mathers, Susan , Nicholson, Garth A. , Pamphlett, Roger , Rowe, Dominic B. , Williams, Kelly L. , Mather, Karen A. , Sachdev, Perminder S. , Wallace, Leanne , Pinto, Susana , Rouleau, Guy A. , Breen, Gerome , Brown, Robert H. , Andersen, Peter M. , McRae, Allan F. , Davey Smith, George , Gaunt, Tom R. , Eberle, Michael A. , Wray, Naomi R. , Van Damme, Philip , Veldink, Jan H. , SLAP Consortium , SLAGEN Consortium , SLALOM Consortium and PARALS Consortium
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with a lifetime risk of one in 350 people and an unmet need for disease-modifying therapies. We conducted a cross-ancestry genome-wide association study (GWAS) including 29,612 patients with ALS and 122,656 controls, which identified 15 risk loci. When combined with 8,953 indi...
Alternative Titles
Full title
Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology
Authors, Artists and Contributors
Author / Creator
van Vugt, Joke J. F. A.
Hop, Paul J.
Westra, Harm-Jan
Deelen, Patrick
Hannon, Eilis
Dolzhenko, Egor
Westeneng, Henk-Jan
Tazelaar, Gijs H. P.
van Eijk, Kristel R.
Kooyman, Maarten
Byrne, Ross P.
Doherty, Mark
Heverin, Mark
Al Khleifat, Ahmad
Iacoangeli, Alfredo
Shatunov, Aleksey
Smith, Bradley N.
Chandran, Siddharthan
Pal, Suvankar
Morrison, Karen E.
Shaw, Pamela J.
Hardy, John
Sendtner, Michael
Meyer, Thomas
Başak, Nazli
van der Kooi, Anneke J.
Ratti, Antonia
Fogh, Isabella
Lauria, Giuseppe
Corti, Stefania
Sorarù, Gianni
Filosto, Massimiliano
Chiò, Adriano
Calvo, Andrea
Brunetti, Maura
Nefussy, Beatrice
Osmanovic, Alma
Lerner, Yossef
Gotkine, Marc
Bell, Shaughn
Vourc’h, Patrick
Corcia, Philippe
Salachas, François
Mora Pardina, Jesus S.
Rojas-García, Ricardo
Ross, Jay P.
Weishaupt, Jochen H.
Brenner, David
Bensimon, Gilbert
Payan, Christine A. M.
Saker-Delye, Safa
Wood, Nicholas W.
Rademakers, Rosa
Lieb, Wolfgang
Olsen, Catherine M.
Uitterlinden, Andre G.
Hofman, Albert
Rietschel, Marcella
Traynor, Bryan J.
Mitne Neto, Miguel
Cauchi, Ruben J.
Gaur, Nayana
Ilse, Benjamin
Stubendorff, Beatrice
Witte, Otto W.
Steinbach, Robert
Graff, Caroline
Ataulina, Anastasia
Rogelj, Boris
Koritnik, Blaž
Zidar, Janez
Ravnik-Glavač, Metka
Glavač, Damjan
Stević, Zorica
Drory, Vivian
Povedano, Monica
Blair, Ian P.
Kiernan, Matthew C.
Furlong, Sarah
Mathers, Susan
Nicholson, Garth A.
Pamphlett, Roger
Rowe, Dominic B.
Williams, Kelly L.
Mather, Karen A.
Sachdev, Perminder S.
Wallace, Leanne
Pinto, Susana
Rouleau, Guy A.
Breen, Gerome
Brown, Robert H.
Andersen, Peter M.
McRae, Allan F.
Davey Smith, George
Gaunt, Tom R.
Eberle, Michael A.
Wray, Naomi R.
Van Damme, Philip
Veldink, Jan H.
SLAP Consortium
SLAGEN Consortium
SLALOM Consortium
PARALS Consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_457083
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_457083
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-021-00973-1
