MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
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Author / Creator
Simone, Roberto , Javad, Faiza , Emmett, Warren , Wilkins, Oscar G. , Almeida, Filipa Lourenço , Barahona-Torres, Natalia , Zareba-Paslawska, Justyna , Ehteramyan, Mazdak , Zuccotti, Paola , Modelska, Angelika , Siva, Kavitha , Virdi, Gurvir S. , Mitchell, Jamie S. , Harley, Jasmine , Kay, Victoria A. , Hondhamuni, Geshanthi , Trabzuni, Daniah , Ryten, Mina , Wray, Selina , Preza, Elisavet , Kia, Demis A. , Pittman, Alan , Ferrari, Raffaele , Manzoni, Claudia , Lees, Andrew , Hardy, John A. , Denti, Michela A. , Quattrone, Alessandro , Patani, Rickie , Svenningsson, Per , Warner, Thomas T. , Plagnol, Vincent , Ule, Jernej and de Silva, Rohan
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
The human genome expresses thousands of natural antisense transcripts (NAT) that can regulate epigenetic state, transcription, RNA stability or translation of their overlapping genes
1
,
2
. Here we describe MAPT-AS1, a brain-enriched NAT that is conserved in primates and contains an embedded mammalian-wide interspersed repeat (MIR), wh...
Alternative Titles
Full title
MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration
Authors, Artists and Contributors
Author / Creator
Javad, Faiza
Emmett, Warren
Wilkins, Oscar G.
Almeida, Filipa Lourenço
Barahona-Torres, Natalia
Zareba-Paslawska, Justyna
Ehteramyan, Mazdak
Zuccotti, Paola
Modelska, Angelika
Siva, Kavitha
Virdi, Gurvir S.
Mitchell, Jamie S.
Harley, Jasmine
Kay, Victoria A.
Hondhamuni, Geshanthi
Trabzuni, Daniah
Ryten, Mina
Wray, Selina
Preza, Elisavet
Kia, Demis A.
Pittman, Alan
Ferrari, Raffaele
Manzoni, Claudia
Lees, Andrew
Hardy, John A.
Denti, Michela A.
Quattrone, Alessandro
Patani, Rickie
Svenningsson, Per
Warner, Thomas T.
Plagnol, Vincent
Ule, Jernej
de Silva, Rohan
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_461902
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_461902
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03556-6
