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Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_462887

Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Publication information

Publisher

Cham: Springer International Publishing

More information

Scope and Contents

Contents

Epidemiological investigations show that mosaic loss of chromosome Y (LOY) in leukocytes is associated with earlier mortality and morbidity from many diseases in men. LOY is the most common acquired mutation and is associated with aberrant clonal expansion of cells, yet it remains unclear whether this mosaicism exerts a direct physiological effect....

Alternative Titles

Full title

Immune cells lacking Y chromosome show dysregulation of autosomal gene expression

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_462887

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_462887

Other Identifiers

ISSN

1420-682X,1420-9071

E-ISSN

1420-9071

DOI

10.1007/s00018-021-03822-w