A specific RIP3⁺ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necropt...
A specific RIP3⁺ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism
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Author / Creator
He, Chang , Liu, Yan , Huang, Zijing , Yang, Ziqi , Zhou, Tian , Liu, Sheng , Hao, Zhaozhe , Wang, Jing , Feng, Qiumin , Liu, Yizhi , Cao, Yihai and Liu, Xialin
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publication information
Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Retinal neovascularization is a leading cause of severe visual loss in humans, and molecular mechanisms of microglial activationdriven angiogenesis remain unknown. Using single-cell RNA sequencing, we identified a subpopulation of microglia named sMG2, which highly expressed necroptosis-related genes Rip3 and Mlkl. Genetic and pharmacological loss...
Alternative Titles
Full title
A specific RIP3⁺ subpopulation of microglia promotes retinopathy through a hypoxia-triggered necroptotic mechanism
Authors, Artists and Contributors
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_462899
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_462899
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2023290118
