Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione re...
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer
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Author / Creator
Rebollido-Rios, Rocio , Venton, Geoffroy , Sánchez-Redondo, Sara , Iglesias i Felip, Carmela , Fournet, Guy , González, Elena , Romero Fernández, Wilber , Borroto Escuela, Dasiel Oscar , Di Stefano, Barbara , Penarroche-Díaz, Reinier , Martin, Guillaume , Ceylan, Ismail , Costello, Regis and Perez-Alea, Mileidys
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Aldehyde dehydrogenases
(
ALDHs
)
are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on The Cancer Genome Atlas and Gene Expression Omnibus data and detected genetic alterations in
ALDH1A1, ALDH1A3
, or
ALDH3A1
, 86% of which were gene amplification or mRNA...
Alternative Titles
Full title
Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_473777
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_473777
Other Identifiers
ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/s41388-020-1184-9
