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Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione re...

Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione re...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_473777

Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

About this item

Full title

Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

Publisher

London: Nature Publishing Group UK

Journal title

Oncogene, 2020-03, Vol.39 (13), p.2756-2771

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

Subjects

Subjects and topics

More information

Scope and Contents

Contents

Aldehyde dehydrogenases
(
ALDHs
)
are multifunctional enzymes that oxidize diverse endogenous and exogenous aldehydes. We conducted a meta-analysis based on The Cancer Genome Atlas and Gene Expression Omnibus data and detected genetic alterations in
ALDH1A1, ALDH1A3
, or
ALDH3A1
, 86% of which were gene amplification or mRNA...

Alternative Titles

Full title

Dual disruption of aldehyde dehydrogenases 1 and 3 promotes functional changes in the glutathione redox system and enhances chemosensitivity in nonsmall cell lung cancer

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_473777

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_473777

Other Identifiers

ISSN

0950-9232,1476-5594

E-ISSN

1476-5594

DOI

10.1038/s41388-020-1184-9