Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, t...
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
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Author / Creator
Alzheimer Disease Genetics Consortium (ADGC) , Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE) , European Alzheimer’s Disease Initiative (EADI) , Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES) , The European Alzheimer’s Disease Initiative (EADI) , Ahmad, Shahzad , Vardarajan, Badri N. , Hoffmann, Per , Garnier, Jean-Guillaume , Harold, Denise , Fitzpatrick, Annette L. , Valladares, Otto , Smith, Albert V. , Qu, Liming , Zhao, Yi , Del Zompo, Maria , Uphill, James , Cantwell, Laura B. , Garzia, Fabienne , Fin, Bertrand , Barber, Robert C. , Mayhaus, Manuel , Hartmann, Annette M. , Lovestone, Simon , Garcia, Melissa E. , Fairchild, Thomas J. , Karamujić-Čomić, Hata , Frosch, Matthew P. , Maier, Wolfgang , Li, Shuo , Huebinger, Ryan M. , Kamboh, M. Ilyas , Yang, Qiong , Haapasalo, Annakaisa , Lawlor, Brian , Solfrizzi, Vincenzo , Frisardi, Vincenza , Alvarez, Ignacio , Salani, Francesca , Fievet, Nathalie , Maletta, Raffaele Giovanni , Tsuang, Debby W. , Soininen, Hilkka , Avramidou, Despoina , Panza, Francesco , Frölich, Lutz , Passmore, Peter , Schott, Jonathan M. , Powell, John F. , Burns, Jeffrey M. , Hardy, John , Carrasquillo, Minerva M. , Crocco, Elizabeth A. , Faber, Kelley M. , Scherer, Martin , Ferris, Steven , Galasko, Douglas R. , Geschwind, Daniel H. , Honig, Lawrence S. , Cushion, Thomas D. , Hollingworth, Paul , Hulette, Christine M. , Jessen, Frank , Lah, James J. , Leverenz, James B. , Morgan, Kevin , Mash, Deborah C. , McCurry, Susan M. , Miller, Carol A. , Shaw, Christopher E. , Myers, Amanda J. , Paulson, Henry L. , Peskind, Elaine , Cribbs, David H. , Rossor, Martin , Pierce, Aimee , Potter, Huntington , Sorbi, Sandro , Reitz, Christiane , Ringman, John M. , Rosen, Howard J. , Mecocci, Patrizia , Slifer, Susan , Spina, Salvatore , Vinters, Harry V. , Weintraub, Sandra , Welsh-Bohmer, Kathleen A. , Crane, Paul K. , Bennett, David , Boccardi, Virginia , Lopez, Oscar L. , Deloukas, Panagiotis , Cruchaga, Carlos , Berr, Claudine , Younkin, Steven G. , Clarimon, Jordi , Schmidt, Reinhold , Farrer, Lindsay A. , Van Broeckhoven, Christine , C. O’Donovan, Michael , Haines, Jonathan L. , Gudnason, Vilmundur , Mayeux, Richard , Seshadri, Sudha and Williams, Julie
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (
IQCK
,
ACE
...
Alternative Titles
Full title
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Authors, Artists and Contributors
Author / Creator
Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium (CHARGE)
European Alzheimer’s Disease Initiative (EADI)
Genetic and Environmental Risk in AD/Defining Genetic, Polygenic and Environmental Risk for Alzheimer’s Disease Consortium (GERAD/PERADES)
The European Alzheimer’s Disease Initiative (EADI)
Ahmad, Shahzad
Vardarajan, Badri N.
Hoffmann, Per
Garnier, Jean-Guillaume
Harold, Denise
Fitzpatrick, Annette L.
Valladares, Otto
Smith, Albert V.
Qu, Liming
Zhao, Yi
Del Zompo, Maria
Uphill, James
Cantwell, Laura B.
Garzia, Fabienne
Fin, Bertrand
Barber, Robert C.
Mayhaus, Manuel
Hartmann, Annette M.
Lovestone, Simon
Garcia, Melissa E.
Fairchild, Thomas J.
Karamujić-Čomić, Hata
Frosch, Matthew P.
Maier, Wolfgang
Li, Shuo
Huebinger, Ryan M.
Kamboh, M. Ilyas
Yang, Qiong
Haapasalo, Annakaisa
Lawlor, Brian
Solfrizzi, Vincenzo
Frisardi, Vincenza
Alvarez, Ignacio
Salani, Francesca
Fievet, Nathalie
Maletta, Raffaele Giovanni
Tsuang, Debby W.
Soininen, Hilkka
Avramidou, Despoina
Panza, Francesco
Frölich, Lutz
Passmore, Peter
Schott, Jonathan M.
Powell, John F.
Burns, Jeffrey M.
Hardy, John
Carrasquillo, Minerva M.
Crocco, Elizabeth A.
Faber, Kelley M.
Scherer, Martin
Ferris, Steven
Galasko, Douglas R.
Geschwind, Daniel H.
Honig, Lawrence S.
Cushion, Thomas D.
Hollingworth, Paul
Hulette, Christine M.
Jessen, Frank
Lah, James J.
Leverenz, James B.
Morgan, Kevin
Mash, Deborah C.
McCurry, Susan M.
Miller, Carol A.
Shaw, Christopher E.
Myers, Amanda J.
Paulson, Henry L.
Peskind, Elaine
Cribbs, David H.
Rossor, Martin
Pierce, Aimee
Potter, Huntington
Sorbi, Sandro
Reitz, Christiane
Ringman, John M.
Rosen, Howard J.
Mecocci, Patrizia
Slifer, Susan
Spina, Salvatore
Vinters, Harry V.
Weintraub, Sandra
Welsh-Bohmer, Kathleen A.
Crane, Paul K.
Bennett, David
Boccardi, Virginia
Lopez, Oscar L.
Deloukas, Panagiotis
Cruchaga, Carlos
Berr, Claudine
Younkin, Steven G.
Clarimon, Jordi
Schmidt, Reinhold
Farrer, Lindsay A.
Van Broeckhoven, Christine
C. O’Donovan, Michael
Haines, Jonathan L.
Gudnason, Vilmundur
Mayeux, Richard
Seshadri, Sudha
Williams, Julie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_481589
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_481589
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-019-0358-2
