Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the impor...
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
About this item
Full title
Author / Creator
Howard, David M. , Adams, Mark J. , Clarke, Toni-Kim , Hafferty, Jonathan D. , Gibson, Jude , Shirali, Masoud , Coleman, Jonathan R. I. , Hagenaars, Saskia P. , Ward, Joey , Wigmore, Eleanor M. , Alloza, Clara , Shen, Xueyi , Barbu, Miruna C. , Xu, Eileen Y. , Whalley, Heather C. , Marioni, Riccardo E. , Porteous, David J. , Davies, Gail , Deary, Ian J. , Hemani, Gibran , Berger, Klaus , Teismann, Henning , Rawal, Rajesh , Arolt, Volker , Baune, Bernhard T. , Dannlowski, Udo , Domschke, Katharina , Tian, Chao , Hinds, David A. , Trzaskowski, Maciej , Byrne, Enda M. , Ripke, Stephan , Smith, Daniel J. , Sullivan, Patrick F. , Wray, Naomi R. , Breen, Gerome , Lewis, Cathryn M. , McIntosh, Andrew M. , Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium and 23andMe Research Team
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Major depression is a debilitating psychiatric illness that is typically associated with low mood and anhedonia. Depression has a heritable component that has remained difficult to elucidate with current sample sizes due to the polygenic nature of the disorder. To maximize sample size, we meta-analyzed data on 807,553 individuals (246,363 cases and...
Alternative Titles
Full title
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Authors, Artists and Contributors
Author / Creator
Adams, Mark J.
Clarke, Toni-Kim
Hafferty, Jonathan D.
Gibson, Jude
Shirali, Masoud
Coleman, Jonathan R. I.
Hagenaars, Saskia P.
Ward, Joey
Wigmore, Eleanor M.
Alloza, Clara
Shen, Xueyi
Barbu, Miruna C.
Xu, Eileen Y.
Whalley, Heather C.
Marioni, Riccardo E.
Porteous, David J.
Davies, Gail
Deary, Ian J.
Hemani, Gibran
Berger, Klaus
Teismann, Henning
Rawal, Rajesh
Arolt, Volker
Baune, Bernhard T.
Dannlowski, Udo
Domschke, Katharina
Tian, Chao
Hinds, David A.
Trzaskowski, Maciej
Byrne, Enda M.
Ripke, Stephan
Smith, Daniel J.
Sullivan, Patrick F.
Wray, Naomi R.
Breen, Gerome
Lewis, Cathryn M.
McIntosh, Andrew M.
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
23andMe Research Team
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_482244
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_482244
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-018-0326-7
