Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals...
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
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23and Me Research Team , eQTLgen Consortium , International Cannabis Consortium , Social Science Genetic Association Consortium , Karlsson Linnér, Richard , Biroli, Pietro , Kong, Edward , Meddens, S. Fleur W. , Wedow, Robbee , Fontana, Mark Alan , Lebreton, Maël , Tino, Stephen P. , Abdellaoui, Abdel , Hammerschlag, Anke R. , Nivard, Michel G. , Okbay, Aysu , Rietveld, Cornelius A. , Timshel, Pascal N. , Trzaskowski, Maciej , Vlaming, Ronald de , Zünd, Christian L. , Bao, Yanchun , Buzdugan, Laura , Caplin, Ann H. , Chen, Chia-Yen , Eibich, Peter , Fontanillas, Pierre , Gonzalez, Juan R. , Joshi, Peter K. , Karhunen, Ville , Kleinman, Aaron , Levin, Remy Z. , Lill, Christina M. , Meddens, Gerardus A. , Muntané, Gerard , Sanchez-Roige, Sandra , Rooij, Frank J. van , Taskesen, Erdogan , Wu, Yang , Zhang, Futao , Auton, Adam , Boardman, Jason D. , Clark, David W. , Conlin, Andrew , Dolan, Conor C. , Fischbacher, Urs , Groenen, Patrick J. F. , Harris, Kathleen Mullan , Hasler, Gregor , Hofman, Albert , Ikram, Mohammad A. , Jain, Sonia , Karlsson, Robert , Kessler, Ronald C. , Kooyman, Maarten , MacKillop, James , Männikkö, Minna , Morcillo-Suarez, Carlos , McQueen, Matthew B. , Schmidt, Klaus M. , Smart, Melissa C. , Sutter, Matthias , Thurik, A. Roy , Uitterlinden, André G. , White, Jon , Wit, Harriet de , Yang, Jian , Bertram, Lars , Boomsma, Dorret I. , Esko, Tõnu , Fehr, Ernst , Hinds, David A. , Johannesson, Magnus , Kumari, Meena , Laibson, David , Magnusson, Patrik K. E. , Meyer, Michelle N. , Navarro, Arcadi , Palmer, Abraham A. , Pers, Tune H. , Posthuma, Danielle , Schunk, Daniel , Stein, Murray B. , Svento, Rauli , Tiemeier, Henning , Timmers, Paul R. H. J. , Turley, Patrick , Ursano, Robert J. , Wagner, Gert G. , Wilson, James F. , Gratten, Jacob , Lee, James J. , Cesarini, David , Benjamin, Daniel J. , Koellinger, Philipp D. and Beauchamp, Jonathan P.
Publisher
New York: Nature Publishing Group US
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Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Humans vary substantially in their willingness to take risks. In a combined sample of over 1 million individuals, we conducted genome-wide association studies (GWAS) of general risk tolerance, adventurousness, and risky behaviors in the driving, drinking, smoking, and sexual domains. Across all GWAS, we identified hundreds of associated loci, inclu...
Alternative Titles
Full title
Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences
Authors, Artists and Contributors
Author / Creator
eQTLgen Consortium
International Cannabis Consortium
Social Science Genetic Association Consortium
Karlsson Linnér, Richard
Biroli, Pietro
Kong, Edward
Meddens, S. Fleur W.
Wedow, Robbee
Fontana, Mark Alan
Lebreton, Maël
Tino, Stephen P.
Abdellaoui, Abdel
Hammerschlag, Anke R.
Nivard, Michel G.
Okbay, Aysu
Rietveld, Cornelius A.
Timshel, Pascal N.
Trzaskowski, Maciej
Vlaming, Ronald de
Zünd, Christian L.
Bao, Yanchun
Buzdugan, Laura
Caplin, Ann H.
Chen, Chia-Yen
Eibich, Peter
Fontanillas, Pierre
Gonzalez, Juan R.
Joshi, Peter K.
Karhunen, Ville
Kleinman, Aaron
Levin, Remy Z.
Lill, Christina M.
Meddens, Gerardus A.
Muntané, Gerard
Sanchez-Roige, Sandra
Rooij, Frank J. van
Taskesen, Erdogan
Wu, Yang
Zhang, Futao
Auton, Adam
Boardman, Jason D.
Clark, David W.
Conlin, Andrew
Dolan, Conor C.
Fischbacher, Urs
Groenen, Patrick J. F.
Harris, Kathleen Mullan
Hasler, Gregor
Hofman, Albert
Ikram, Mohammad A.
Jain, Sonia
Karlsson, Robert
Kessler, Ronald C.
Kooyman, Maarten
MacKillop, James
Männikkö, Minna
Morcillo-Suarez, Carlos
McQueen, Matthew B.
Schmidt, Klaus M.
Smart, Melissa C.
Sutter, Matthias
Thurik, A. Roy
Uitterlinden, André G.
White, Jon
Wit, Harriet de
Yang, Jian
Bertram, Lars
Boomsma, Dorret I.
Esko, Tõnu
Fehr, Ernst
Hinds, David A.
Johannesson, Magnus
Kumari, Meena
Laibson, David
Magnusson, Patrik K. E.
Meyer, Michelle N.
Navarro, Arcadi
Palmer, Abraham A.
Pers, Tune H.
Posthuma, Danielle
Schunk, Daniel
Stein, Murray B.
Svento, Rauli
Tiemeier, Henning
Timmers, Paul R. H. J.
Turley, Patrick
Ursano, Robert J.
Wagner, Gert G.
Wilson, James F.
Gratten, Jacob
Lee, James J.
Cesarini, David
Benjamin, Daniel J.
Koellinger, Philipp D.
Beauchamp, Jonathan P.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_482786
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_482786
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-018-0309-3
