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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

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Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_492117

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

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Publication information

Publisher

London: Nature Publishing Group UK

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Scope and Contents

Contents

Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A promising approach to meet the need for improved cancer treatment is drug repurposing. Here we highlight the potential for repurposing disulfiram (also known by the trade name Antabuse), an old alcohol-aversion drug that has be...

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Full title

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

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Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_492117

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_492117

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature25016

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