Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cance...
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
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Author / Creator
Hessmann, E , Patzak, M S , Klein, L , Chen, N , Kari, V , Ramu, I , Bapiro, T E , Frese, K K , Gopinathan, A , Richards, F M , Jodrell, D I , Verbeke, C , Li, X , Heuchel, R , Löhr, J M , Johnsen, S A , Gress, T M , Ellenrieder, V and Neesse, A
Publisher
England: BMJ Publishing Group LTD
Journal title
Language
English
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Publisher
England: BMJ Publishing Group LTD
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Scope and Contents
Contents
ObjectiveDesmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery.DesignGemcitabine metaboli...
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Full title
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
Authors, Artists and Contributors
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_499832
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_499832
Other Identifiers
ISSN
0017-5749
E-ISSN
1468-3288
DOI
10.1136/gutjnl-2016-311954
