CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
About this item
Full title
Author / Creator
Kojima, Yoko , Volkmer, Jens-Peter , McKenna, Kelly , Civelek, Mete , Lusis, Aldons Jake , Miller, Clint L. , Direnzo, Daniel , Nanda, Vivek , Ye, Jianqin , Connolly, Andrew J. , Schadt, Eric E. , Quertermous, Thomas , Betancur, Paola , Maegdefessel, Lars , Matic, Ljubica Perisic , Hedin, Ulf , Weissman, Irving L. and Leeper, Nicholas J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Atherosclerotic lesions in mice and humans switch on a ‘don’t eat me’ signal—expression of CD47—that prevents effective removal of diseased tissue; anti-CD47 antibody therapy can normalize this defective efferocytosis, with beneficial results in several mouse models of atherosclerosis.
Pathogenesis mechanisms in atherosclerosis
Nicholas Leepe...
Alternative Titles
Full title
CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
Authors, Artists and Contributors
Author / Creator
Volkmer, Jens-Peter
McKenna, Kelly
Civelek, Mete
Lusis, Aldons Jake
Miller, Clint L.
Direnzo, Daniel
Nanda, Vivek
Ye, Jianqin
Connolly, Andrew J.
Schadt, Eric E.
Quertermous, Thomas
Betancur, Paola
Maegdefessel, Lars
Matic, Ljubica Perisic
Hedin, Ulf
Weissman, Irving L.
Leeper, Nicholas J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_503721
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_503721
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature18935
