Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease
Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease
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Author / Creator
Laguna, Ariadna , Schintu, Nicoletta , Nobre, André , Alvarsson, Alexandra , Volakakis, Nikolaos , Jacobsen, Jesper Kjaer , Gómez-Galán, Marta , Sopova, Elena , Joodmardi, Eliza , Yoshitake, Takashi , Deng, Qiaolin , Kehr, Jan , Ericson, Johan , Svenningsson, Per , Shupliakov, Oleg and Perlmann, Thomas
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
This study establishes a key role for the developmental transcription factors Lmx1a/b in the maintenance of midbrain dopamine neurons. The authors show that postmitotic ablation of Lmx1b in mice leads to cellular and functional abnormalities resembling Parkinson's disease, most notably in a dysfunction in the autophagic-lysosomal pathway that resul...
Alternative Titles
Full title
Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease
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Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_513934
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_513934
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.4004
