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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive...

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_539330

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

About this item

Full title

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

Publisher

New York: Nature Publishing Group US

Journal title

Nature genetics, 2012-03, Vol.44 (3), p.291-296

Language

English

Formats

Publication information

Publisher

New York: Nature Publishing Group US

More information

Scope and Contents

Contents

Soumya Raychaudhuri, Paul de Bakker and colleagues report fine mapping of the rheumatoid arthritis associations within the MHC by combining genome-wide SNP data and imputation of classical HLA alleles and SNPs across the MHC. They identify five amino acid positions in HLA-DRβ1, HLA-B and HLA-DPβ1 that together can explain most of the MHC associatio...

Alternative Titles

Full title

Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_539330

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_539330

Other Identifiers

ISSN

1061-4036

E-ISSN

1546-1718

DOI

10.1038/ng.1076