Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
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Publisher
Washington, DC: American Association for the Advancement of Science
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English
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Washington, DC: American Association for the Advancement of Science
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Contents
Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to impaired insulin granule docking at the plasma membrane and reduced β cell exocytosis. In...
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Full title
Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes
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TN_cdi_swepub_primary_oai_swepub_ki_se_554352
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_554352
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ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.1176827
