Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_554352

Overexpression of Alpha2A-Adrenergic Receptors Contributes to Type 2 Diabetes

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Faculty of Medicine , Medicinska fakulteten , Strategiska forskningsområden (SFO) , Translationell muskelforskning , Department of Experimental Medical Science , Diabetes - Islet Patophysiology , Genetik , Institutionen för kliniska vetenskaper, Malmö , Strategic research areas (SRA) , Lunds universitet , Diabetes - öcellsexocytos , Translational Muscle Research , Profilområden och andra starka forskningsmiljöer , Lund University , EXODIAB: Excellence of Diabetes Research in Sweden , Immunologi , Diabetes - öpatofysiologi , Institutionen för experimentell medicinsk vetenskap , Diabetes - Islet Cell Exocytosis , Profile areas and other strong research environments , Genetics , Immunology , Department of Clinical Sciences, Malmö , Rosengren, Anders H , Jokubka, Ramunas , Tojjar, Damon , Granhall, Charlotte , Hansson, Ola , Li, Dai-Qing , Nagaraj, Vini , Reinbothe, Thomas M , Tuncel, Jonatan , Eliasson, Lena , Groop, Leif , Rorsman, Patrik , Salehi, Albert , Lyssenko, Valeriya , Luthman, Holger and Renström, Erik

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Washington, DC: American Association for the Advancement of Science

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Science (American Association for the Advancement of Science), 2010-01, Vol.327 (5962), p.217-220

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English

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Washington, DC: American Association for the Advancement of Science

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Several common genetic variations have been associated with type 2 diabetes, but the exact disease mechanisms are still poorly elucidated. Using congenic strains from the diabetic Goto-Kakizaki rat, we identified a 1.4-megabase genomic locus that was linked to impaired insulin granule docking at the plasma membrane and reduced β cell exocytosis. In...