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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_559254

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

About this item

Full title

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

Publisher

London: Nature Publishing Group UK

Journal title

The pharmacogenomics journal, 2009-06, Vol.9 (3), p.208-217

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

The basis for interindividual variation in the
CYP1A2
gene expression is not fully understood and the known genetic polymorphisms in the gene provide no explanation. We investigated whether the
CYP1A2
gene expression is regulated by DNA methylation and displays allele-specific expression (ASE) using 65 human livers. Forty-eight percent...

Alternative Titles

Full title

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_559254

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_559254

Other Identifiers

ISSN

1470-269X,1473-1150

E-ISSN

1473-1150

DOI

10.1038/tpj.2009.4