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ArticlesPeer ReviewedFull Text
The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals
Author / Creator:Haeggström, Sigrid ; Ingelman-Sundberg, Magnus ; Pääbo, Svante ; Zeberg, Hugo
Publisher:New York: Nature Publishing Group
Journal title:The pharmacogenomics journal, 2022-07, Vol.22 (4), p.247-249
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Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism
Author / Creator:Smutny Tomas ; Hyrsova Lucie ; Braeuning, Albert ; Ingelman-Sundberg Magnus ; Pavek Petr
Publisher:Heidelberg: Springer Nature B.V
Journal title:Archives of toxicology, 2021-01, Vol.95 (1), p.11-25
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Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population
Author / Creator:Bråten, Line Skute ; Ingelman‐Sundberg, Magnus ; Jukic, Marin M. ; Molden, Espen ; Kringen, Marianne Kristiansen
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2022-09, Vol.15 (9), p.2135-2145
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A 3D Cell Culture Model Identifies Wnt/β‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration
Author / Creator:Oliva‐Vilarnau, Nuria ; Vorrink, Sabine U. ; Ingelman‐Sundberg, Magnus ; Lauschke, Volker M.
Publisher:Hoboken: John Wiley and Sons Inc
Journal title:Advanced science, 2020-08, Vol.7 (15), p.2000248-n/a
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Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man
Author / Creator:Dragovic, Sanja ; Vermeulen, Nico P. E. ; Gerets, Helga H. ; Hewitt, Philip G. ; Ingelman‐Sundberg, Magnus ; Park, B. Kevin ; Juhila, Satu ; Snoeys, Jan ; Weaver, Richard J.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Archives of toxicology, 2016-12, Vol.90 (12), p.2979-3003
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Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6‐catalyzed metabolism of solanidine
Author / Creator:Smith, Robert Løvsletten ; Wollmann, Birgit M. ; Størset, Elisabet ; Lenk, Hasan Çağın ; O'Connell, Kevin S. ; Kristiansen, Marianne Kringen ; Ingelman‐Sundberg, Magnus ; Molden, Espen
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2024-02, Vol.17 (2), p.e13743-n/a
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Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits
Author / Creator:Lenk, Hasan Çağın ; Løvsletten Smith, Robert ; O'Connell, Kevin S. ; Jukić, Marin M. ; Kringen, Marianne Kristiansen ; Andreassen, Ole A. ; Ingelman‐Sundberg, Magnus ; Molden, Espen
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2023-01, Vol.16 (1), p.62-72
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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis
Author / Creator:Edsbagge, Josefina ; Johansson, Inger ; Sartipy, Peter ; Ingelman-Sundberg, Magnus ; Holmgren, Gustav ; Jacobsson, Susanna ; Steel, Daniella ; Pradip, Arvind ; Björquist, Petter
Publisher:Cairo, Egypt: Hindawi Limiteds
Journal title:Stem Cells International, 2016-01, Vol.2016 (2016), p.1080-1093-090
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CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload
Author / Creator:Harjumäki, Riina ; Pridgeon, Chris S. ; Ingelman-Sundberg, Magnus
Publisher:Basel: MDPI AG
Journal title:International journal of molecular sciences, 2021-08, Vol.22 (15), p.8221
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Integrating rare genetic variants into pharmacogenetic drug response predictions
Author / Creator:Ingelman-Sundberg, Magnus ; Mkrtchian, Souren ; Zhou, Yitian ; Lauschke, Volker M.
Publisher:England: BioMed Central
Journal title:Human genomics, 2018-05, Vol.12 (1), p.26-12, Article 26
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Human hepatic 3D spheroids as a model for steatosis and insulin resistance
Author / Creator:Kozyra, Mikael ; Johansson, Inger ; Nordling, Åsa ; Ullah, Shahid ; Lauschke, Volker M. ; Ingelman-Sundberg, Magnus
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-09, Vol.8 (1), p.14297-12, Article 14297
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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers
Author / Creator:Ghotbi, Roza ; Gomez, Alvin ; Milani, Lili ; Tybring, Gunnel ; Syvänen, Ann-Christine ; Bertilsson, Leif ; Ingelman-Sundberg, Magnus ; Aklillu, Eleni
Publisher:London: Nature Publishing Group UK
Journal title:The pharmacogenomics journal, 2009-06, Vol.9 (3), p.208-217
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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models
Author / Creator:Weaver, Richard J. ; Blomme, Eric A. ; Chadwick, Amy E. ; Copple, Ian M. ; Gerets, Helga H. J. ; Goldring, Christopher E. ; Guillouzo, Andre ; Hewitt, Philip G. ; Ingelman-Sundberg, Magnus ; Jensen, Klaus Gjervig ; Juhila, Satu ; Klingmüller, Ursula ; Labbe, Gilles ; Liguori, Michael J. ; Lovatt, Cerys A. ; Morgan, Paul ; Naisbitt, Dean J. ; Pieters, Raymond H. H. ; Snoeys, Jan ; van de Water, Bob ; Williams, Dominic P. ; Park, B. Kevin
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2020-02, Vol.19 (2), p.131-148
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The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity
Author / Creator:Lauschke, Volker ; Ingelman-Sundberg, Magnus
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2016-10, Vol.17 (10), p.1714-1714
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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Author / Creator:Bell, Catherine C. ; Hendriks, Delilah F. G. ; Moro, Sabrina M. L. ; Ellis, Ewa ; Walsh, Joanne ; Renblom, Anna ; Fredriksson Puigvert, Lisa ; Dankers, Anita C. A. ; Jacobs, Frank ; Snoeys, Jan ; Sison-Young, Rowena L. ; Jenkins, Rosalind E. ; Nordling, Åsa ; Mkrtchian, Souren ; Park, B. Kevin ; Kitteringham, Neil R. ; Goldring, Christopher E. P. ; Lauschke, Volker M. ; Ingelman-Sundberg, Magnus
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2016-05, Vol.6 (1), p.25187, Article 25187
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Pharmacogenomic Biomarkers for Prediction of Severe Adverse Drug Reactions
Author / Creator:Ingelman-Sundberg, Magnus
Publisher:United States: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2008-02, Vol.358 (6), p.637-639
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Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics
Author / Creator:Santos, María ; Niemi, Mikko ; Hiratsuka, Masahiro ; Kumondai, Masaki ; Ingelman-Sundberg, Magnus ; Lauschke, Volker M ; Rodríguez-Antona, Cristina
Publisher:New York: Nature Publishing Group US
Journal title:Genetics in medicine, 2018-06, Vol.20 (6), p.622-629
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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids
Author / Creator:Prill, Sebastian ; Caddeo, Andrea ; Baselli, Guido ; Jamialahmadi, Oveis ; Dongiovanni, Paola ; Rametta, Raffaela ; Kanebratt, Kajsa P. ; Pujia, Arturo ; Pingitore, Piero ; Mancina, Rosellina Margherita ; Lindén, Daniel ; Whatling, Carl ; Janefeldt, Annika ; Kozyra, Mikael ; Ingelman-Sundberg, Magnus ; Valenti, Luca ; Andersson, Tommy B. ; Romeo, Stefano
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-08, Vol.9 (1), p.11585-11585, Article 11585
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Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model
Author / Creator:Redenšek Trampuž, Sara ; van Riet, Sander ; Nordling, Åsa ; Ingelman-Sundberg, Magnus
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2024-01, Vol.14 (1), p.1396-1396, Article 1396
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AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis
Author / Creator:Cordero-Herrera, Isabel ; Kozyra, Mikael ; Zhuge, Zhengbing ; Haworth, Sarah McCann ; Moretti, Chiara ; Peleli, Maria ; Caldeira-Dias, Mayara ; Jahandideh, Arghavan ; Huirong, Han ; de Campos Cruz, Josiane ; Kleschyov, Andrei L. ; Montenegro, Marcelo F. ; Ingelman-Sundberg, Magnus ; Weitzberg, Eddie ; Lundberg, Jon O. ; Carlstrom, Mattias
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2019-01, Vol.116 (1), p.217-226
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Showing 1 to 20 of 90 results

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The clinically relevant CYP2C83 and CYP2C92 haplotype is inherited from Neandertals

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Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism

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Impact of the novel CYP2C:TG haplotype and CYP2B6 variants on sertraline exposure in a large patient population

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A 3D Cell Culture Model Identifies Wnt/β‐Catenin Mediated Inhibition of p53 as a Critical Step during Human Hepatocyte Regeneration

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Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

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Effect of the NFIB rs28379954 T>C polymorphism on CYP2D6‐catalyzed metabolism of solanidine

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Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits

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High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis

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CYP2E1 in Alcoholic and Non-Alcoholic Liver Injury. Roles of ROS, Reactive Intermediates and Lipid Overload

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Integrating rare genetic variants into pharmacogenetic drug response predictions

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Human hepatic 3D spheroids as a model for steatosis and insulin resistance

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Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers

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Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models

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The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

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Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease

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Pharmacogenomic Biomarkers for Prediction of Severe Adverse Drug Reactions

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Novel copy-number variations in pharmacogenes contribute to interindividual differences in drug pharmacokinetics

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The TM6SF2 E167K genetic variant induces lipid biosynthesis and reduces apolipoprotein B secretion in human hepatic 3D spheroids

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Mechanisms of 5-HT receptor antagonists in the regulation of fibrosis in a 3D human liver spheroid model

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AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

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