Calreticulin exposure dictates the immunogenicity of cancer cell death
Calreticulin exposure dictates the immunogenicity of cancer cell death
About this item
Full title
Author / Creator
Obeid, Michel , Tesniere, Antoine , Ghiringhelli, François , Fimia, Gian Maria , Apetoh, Lionel , Perfettini, Jean-Luc , Castedo, Maria , Mignot, Grégoire , Panaretakis, Theoharis , Casares, Noelia , Métivier, Didier , Larochette, Nathanael , van Endert, Peter , Ciccosanti, Fabiola , Piacentini, Mauro , Zitvogel, Laurence and Kroemer, Guido
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Anthracyclin-treated tumor cells are particularly effective in eliciting an anticancer immune response, whereas other DNA-damaging agents such as etoposide and mitomycin C do not induce immunogenic cell death. Here we show that anthracyclins induce the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface. Blockade or knockdow...
Alternative Titles
Full title
Calreticulin exposure dictates the immunogenicity of cancer cell death
Authors, Artists and Contributors
Author / Creator
Tesniere, Antoine
Ghiringhelli, François
Fimia, Gian Maria
Apetoh, Lionel
Perfettini, Jean-Luc
Castedo, Maria
Mignot, Grégoire
Panaretakis, Theoharis
Casares, Noelia
Métivier, Didier
Larochette, Nathanael
van Endert, Peter
Ciccosanti, Fabiola
Piacentini, Mauro
Zitvogel, Laurence
Kroemer, Guido
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_572394
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_572394
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X,1744-7933
DOI
10.1038/nm1523
