Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlig...
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
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Author / Creator
Roychowdhury, Tanmoy , Klarin, Derek , Levin, Michael G. , Spin, Joshua M. , Rhee, Yae Hyun , Deng, Alicia , Headley, Colwyn A. , Tsao, Noah L. , Gellatly, Corry , Zuber, Verena , Shen, Fred , Hornsby, Whitney E. , Laursen, Ina Holst , Verma, Shefali S. , Locke, Adam E. , Einarsson, Gudmundur , Thorleifsson, Gudmar , Graham, Sarah E. , Dikilitas, Ozan , Pattee, Jack W. , Judy, Renae L. , Pauls-Verges, Ferran , Nielsen, Jonas B. , Wolford, Brooke N. , Brumpton, Ben M. , Dilmé, Jaume , Peypoch, Olga , Juscafresa, Laura Calsina , Edwards, Todd L. , Li, Dadong , Banasik, Karina , Brunak, Søren , Jacobsen, Rikke L. , Garcia-Barrio, Minerva T. , Zhang, Jifeng , Rasmussen, Lars M. , Lee, Regent , Handa, Ashok , Wanhainen, Anders , Mani, Kevin , Lindholt, Jes S. , Obel, Lasse M. , Strauss, Ewa , Oszkinis, Grzegorz , Nelson, Christopher P. , Saxby, Katie L. , van Herwaarden, Joost A. , van der Laan, Sander W. , van Setten, Jessica , Camacho, Mercedes , Davis, Frank M. , Wasikowski, Rachael , Tsoi, Lam C. , Gudjonsson, Johann E. , Eliason, Jonathan L. , Coleman, Dawn M. , Henke, Peter K. , Ganesh, Santhi K. , Chen, Y. Eugene , Guan, Weihua , Pankow, James S. , Pankratz, Nathan , Pedersen, Ole B. , Erikstrup, Christian , Tang, Weihong , Hveem, Kristian , Gudbjartsson, Daniel , Gretarsdottir, Solveig , Thorsteinsdottir, Unnur , Holm, Hilma , Stefansson, Kari , Ferreira, Manuel A. , Baras, Aris , Kullo, Iftikhar J. , Ritchie, Marylyn D. , Christensen, Alex H. , Iversen, Kasper K. , Eldrup, Nikolaj , Sillesen, Henrik , Ostrowski, Sisse R. , Bundgaard, Henning , Ullum, Henrik , Burgess, Stephen , Gill, Dipender , Gallagher, Katherine , Sabater-Lleal, Maria , Surakka, Ida , Jones, Gregory T. , Bown, Matthew J. , Tsao, Philip S. , Willer, Cristen J. , Damrauer, Scott M. , VA Million Veteran Program , DBDS Genomic Consortium , UK Aneurysm Growth Study , DiscovEHR and Regeneron Genetics Center
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Abdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and uncovered 141 independent associations, including 97 previously unreported loci. A polygenic risk score derived from meta-analysis explained AAA risk beyond clinical ris...
Alternative Titles
Full title
Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target
Authors, Artists and Contributors
Author / Creator
Klarin, Derek
Levin, Michael G.
Spin, Joshua M.
Rhee, Yae Hyun
Deng, Alicia
Headley, Colwyn A.
Tsao, Noah L.
Gellatly, Corry
Zuber, Verena
Shen, Fred
Hornsby, Whitney E.
Laursen, Ina Holst
Verma, Shefali S.
Locke, Adam E.
Einarsson, Gudmundur
Thorleifsson, Gudmar
Graham, Sarah E.
Dikilitas, Ozan
Pattee, Jack W.
Judy, Renae L.
Pauls-Verges, Ferran
Nielsen, Jonas B.
Wolford, Brooke N.
Brumpton, Ben M.
Dilmé, Jaume
Peypoch, Olga
Juscafresa, Laura Calsina
Edwards, Todd L.
Li, Dadong
Banasik, Karina
Brunak, Søren
Jacobsen, Rikke L.
Garcia-Barrio, Minerva T.
Zhang, Jifeng
Rasmussen, Lars M.
Lee, Regent
Handa, Ashok
Wanhainen, Anders
Mani, Kevin
Lindholt, Jes S.
Obel, Lasse M.
Strauss, Ewa
Oszkinis, Grzegorz
Nelson, Christopher P.
Saxby, Katie L.
van Herwaarden, Joost A.
van der Laan, Sander W.
van Setten, Jessica
Camacho, Mercedes
Davis, Frank M.
Wasikowski, Rachael
Tsoi, Lam C.
Gudjonsson, Johann E.
Eliason, Jonathan L.
Coleman, Dawn M.
Henke, Peter K.
Ganesh, Santhi K.
Chen, Y. Eugene
Guan, Weihua
Pankow, James S.
Pankratz, Nathan
Pedersen, Ole B.
Erikstrup, Christian
Tang, Weihong
Hveem, Kristian
Gudbjartsson, Daniel
Gretarsdottir, Solveig
Thorsteinsdottir, Unnur
Holm, Hilma
Stefansson, Kari
Ferreira, Manuel A.
Baras, Aris
Kullo, Iftikhar J.
Ritchie, Marylyn D.
Christensen, Alex H.
Iversen, Kasper K.
Eldrup, Nikolaj
Sillesen, Henrik
Ostrowski, Sisse R.
Bundgaard, Henning
Ullum, Henrik
Burgess, Stephen
Gill, Dipender
Gallagher, Katherine
Sabater-Lleal, Maria
Surakka, Ida
Jones, Gregory T.
Bown, Matthew J.
Tsao, Philip S.
Willer, Cristen J.
Damrauer, Scott M.
VA Million Veteran Program
DBDS Genomic Consortium
UK Aneurysm Growth Study
DiscovEHR
Regeneron Genetics Center
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_824601
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_824601
Other Identifiers
ISSN
1061-4036,1546-1718
E-ISSN
1546-1718
DOI
10.1038/s41588-023-01510-y
