Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with ca...
Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1
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Author / Creator
Zhou, Li , Wu, Dongxiao , Zhou, Yabo , Wang, Dianheng , Fu, Haixia , Huang, Qiusha , Qin, Guohui , Chen, Jie , Lv, Jiadi , Lai, Shaoyang , Zhang, Huafeng , Tang, Ke , Ma, Jingwei , Fiskesund, Roland , Zhang, Yi , Zhang, Xiaohui and Huang, Bo
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Tumor-derived factors are thought to regulate thrombocytosis and erythrocytopenia in individuals with cancer; however, such factors have not yet been identified. Here we show that tumor cell-released kynurenine (Kyn) biases megakaryocytic–erythroid progenitor cell (MEP) differentiation into megakaryocytes in individuals with cancer by activating th...
Alternative Titles
Full title
Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR–RUNX1
Authors, Artists and Contributors
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_830112
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_830112
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-023-01662-3
