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Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_831466

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

About this item

Full title

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Author / Creator

NF-κB Consortium , COVID Human Genetic Effort , Le Voyer, Tom , Parent, Audrey V. , Liu, Xian , Cederholm, Axel , Gervais, Adrian , Rosain, Jérémie , Nguyen, Tina , Perez Lorenzo, Malena , Rinchai, Darawan , Zhang, Peng , Hancioglu, Gonca , Ghillani-Dalbin, Pascale , Charuel, Jean-Luc , Philippot, Quentin , Gueye, Mame Sokhna , Soudée, Camille , Rozenberg, Flore , Momenilandi, Mana , Riller, Quentin , Delmonte, Ottavia M. , Müller, Gabriele , Keller, Baerbel , Orrego, Julio , Rubin, Tamar , Emiroglu, Melike , Eriksson, Daniel , Katelaris, Constance H. , Mustillo, Peter , Raedler, Johannes , Bohlen, Jonathan , Bengi Celik, Jale , Astudillo, Camila , Winter, Sarah , Guffroy, Aurélien , DeRisi, Joseph L. , Yu, David , Miller, Corey , Feng, Yi , Guichard, Audrey , Béziat, Vivien , Bustamante, Jacinta , Pan-Hammarström, Qiang , Rosen, Lindsey B. , Bosticardo, Marita , Kenney, Heather , Castagnoli, Riccardo , Slade, Charlotte A. , Boztuğ, Kaan , Latour, Sylvain , Sediva, Anna , Atschekzei, Faranaz , Sogkas, Georgios , Poli, M. Cecilia , Palterer, Boaz , Keller, Michael D. , Pinzon-Charry, Alberto , Sullivan, Anna , Droney, Luke , Suan, Daniel , Wong, Melanie , Ma, Cindy , Dalal, Ilan , Hie, Miguel , Lazaro, Estibaliz , Franco, Jose , Malphettes, Marion , Pasquet, Marlene , Maccari, Maria Elena , Frosk, Patrick , Goodnow, Christopher C. , Gray, Paul E. , Belot, Alexandre , Kuehn, Hye Sun , Servettaz, Amélie , Barlogis, Vincent , Le Guenno, Guillaume , Herrmann, Vera-Maria , Kuijpers, Taco , Ducoux, Grégoire , Sarrot-Reynauld, Françoise , Schuetz, Catharina , Cunningham-Rundles, Charlotte , Rieux-Laucat, Frédéric , Tangye, Stuart G. , Doffinger, Rainer , Grimbacher, Bodo , Berteloot, Laureline , Trouillet Assant, Sophie , Su, Helen , Abel, Laurent , Zhang, Qian , Boisson, Bertrand , Cobat, Aurélie , Jouanguy, Emmanuelle , Kampe, Olle , Bastard, Paul , Roifman, Chaim M. , Notarangelo, Luigi D. , Anderson, Mark S. and Casanova, Jean-Laurent

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2023-11, Vol.623 (7988), p.803-813

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)
1
,
2
, conferring a predisposition to life-threatening COVID-19 pneumonia
3
. Here we report that patients with autosomal recessive NIK or RELB deficien...

Alternative Titles

Full title

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Authors, Artists and Contributors

Author / Creator

NF-κB Consortium
COVID Human Genetic Effort
Le Voyer, Tom
Parent, Audrey V.
Liu, Xian
Cederholm, Axel
Gervais, Adrian
Rosain, Jérémie
Nguyen, Tina
Perez Lorenzo, Malena
Rinchai, Darawan
Zhang, Peng
Hancioglu, Gonca
Ghillani-Dalbin, Pascale
Charuel, Jean-Luc
Philippot, Quentin
Gueye, Mame Sokhna
Soudée, Camille
Rozenberg, Flore
Momenilandi, Mana
Riller, Quentin
Delmonte, Ottavia M.
Müller, Gabriele
Keller, Baerbel
Orrego, Julio
Rubin, Tamar
Emiroglu, Melike
Eriksson, Daniel
Katelaris, Constance H.
Mustillo, Peter
Raedler, Johannes
Bohlen, Jonathan
Bengi Celik, Jale
Astudillo, Camila
Winter, Sarah
Guffroy, Aurélien
DeRisi, Joseph L.
Yu, David
Miller, Corey
Feng, Yi
Guichard, Audrey
Béziat, Vivien
Bustamante, Jacinta
Pan-Hammarström, Qiang
Rosen, Lindsey B.
Bosticardo, Marita
Kenney, Heather
Castagnoli, Riccardo
Slade, Charlotte A.
Boztuğ, Kaan
Latour, Sylvain
Sediva, Anna
Atschekzei, Faranaz
Sogkas, Georgios
Poli, M. Cecilia
Palterer, Boaz
Keller, Michael D.
Pinzon-Charry, Alberto
Sullivan, Anna
Droney, Luke
Suan, Daniel
Wong, Melanie
Ma, Cindy
Dalal, Ilan
Hie, Miguel
Lazaro, Estibaliz
Franco, Jose
Malphettes, Marion
Pasquet, Marlene
Maccari, Maria Elena
Frosk, Patrick
Goodnow, Christopher C.
Gray, Paul E.
Belot, Alexandre
Kuehn, Hye Sun
Servettaz, Amélie
Barlogis, Vincent
Le Guenno, Guillaume
Herrmann, Vera-Maria
Kuijpers, Taco
Ducoux, Grégoire
Sarrot-Reynauld, Françoise
Schuetz, Catharina
Cunningham-Rundles, Charlotte
Rieux-Laucat, Frédéric
Tangye, Stuart G.
Doffinger, Rainer
Grimbacher, Bodo
Berteloot, Laureline
Trouillet Assant, Sophie
Su, Helen
Abel, Laurent
Zhang, Qian
Boisson, Bertrand
Cobat, Aurélie
Jouanguy, Emmanuelle
Kampe, Olle
Bastard, Paul
Roifman, Chaim M.
Notarangelo, Luigi D.
Anderson, Mark S.
Casanova, Jean-Laurent

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_swepub_primary_oai_swepub_ki_se_831466

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_831466

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/s41586-023-06717-x