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Select record 21
ArticlesPeer ReviewedFull Text
Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer
Author / Creator:Shaw, Alice T ; Ou, Sai-Hong I ; Bang, Yung-Jue ; Camidge, D. Ross ; Solomon, Benjamin J ; Salgia, Ravi ; Riely, Gregory J ; Varella-Garcia, Marileila ; Shapiro, Geoffrey I ; Costa, Daniel B ; Doebele, Robert C ; Le, Long Phi ; Zheng, Zongli ; Tan, Weiwei ; Stephenson, Patricia ; Shreeve, S. Martin ; Tye, Lesley M ; Christensen, James G ; Wilner, Keith D ; Clark, Jeffrey W ; Iafrate, A. John
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2014-11, Vol.371 (21), p.1963-1971
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The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy
Author / Creator:Briere, David ; Niranjan Sudhakar ; Woods, David M ; Hallin, Jill ; Engstrom, Lars D ; Aranda, Ruth ; Chiang, Harrah ; Sodré, Andressa L ; Olson, Peter ; Weber, Jeffrey S ; Christensen, James G
Publisher:Heidelberg: Springer Nature B.V
Journal title:Cancer immunology, immunotherapy, 2018-03, Vol.67 (3), p.381-392
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ArticlesPeer ReviewedFull Text
Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
Author / Creator:Kwak, Eunice L ; Bang, Yung-Jue ; Camidge, D. Ross ; Shaw, Alice T ; Solomon, Benjamin ; Maki, Robert G ; Ou, Sai-Hong I ; Dezube, Bruce J ; Jänne, Pasi A ; Costa, Daniel B ; Varella-Garcia, Marileila ; Kim, Woo-Ho ; Lynch, Thomas J ; Fidias, Panos ; Stubbs, Hannah ; Engelman, Jeffrey A ; Sequist, Lecia V ; Tan, WeiWei ; Gandhi, Leena ; Mino-Kenudson, Mari ; Wei, Greg C ; Shreeve, S. Martin ; Ratain, Mark J ; Settleman, Jeffrey ; Christensen, James G ; Haber, Daniel A ; Wilner, Keith ; Salgia, Ravi ; Shapiro, Geoffrey I ; Clark, Jeffrey W ; Iafrate, A. John
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2010-10, Vol.363 (18), p.1693-1703
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Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor
Author / Creator:Butrynski, James E ; D'Adamo, David R ; Hornick, Jason L ; Dal Cin, Paola ; Antonescu, Cristina R ; Jhanwar, Suresh C ; Ladanyi, Marc ; Capelletti, Marzia ; Rodig, Scott J ; Ramaiya, Nikhil ; Kwak, Eunice L ; Clark, Jeffrey W ; Wilner, Keith D ; Christensen, James G ; Jänne, Pasi A ; Maki, Robert G ; Demetri, George D ; Shapiro, Geoffrey I
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2010-10, Vol.363 (18), p.1727-1733
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Acquired Resistance to Crizotinib from a Mutation in CD74–ROS1
Author / Creator:Awad, Mark M ; Katayama, Ryohei ; McTigue, Michele ; Liu, Wei ; Deng, Ya-Li ; Brooun, Alexei ; Friboulet, Luc ; Huang, Donghui ; Falk, Matthew D ; Timofeevski, Sergei ; Wilner, Keith D ; Lockerman, Elizabeth L ; Khan, Tahsin M ; Mahmood, Sidra ; Gainor, Justin F ; Digumarthy, Subba R ; Stone, James R ; Mino-Kenudson, Mari ; Christensen, James G ; Iafrate, A. John ; Engelman, Jeffrey A ; Shaw, Alice T
Publisher:Waltham, MA: Massachusetts Medical Society
Journal title:The New England journal of medicine, 2013-06, Vol.368 (25), p.2395-2401
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ArticlesPeer ReviewedFull Text
An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice
Author / Creator:Kinross, Kathryn M. ; Montgomery, Karen G. ; Kleinschmidt, Margarete ; Waring, Paul ; Ivetac, Ivan ; Tikoo, Anjali ; Saad, Mirette ; Hare, Lauren ; Roh, Vincent ; Mantamadiotis, Theo ; Sheppard, Karen E. ; Ryland, Georgina L. ; Campbell, Ian G. ; Gorringe, Kylie L. ; Christensen, James G. ; Cullinane, Carleen ; Hicks, Rodney J. ; Pearson, Richard B. ; Johnstone, Ricky W. ; McArthur, Grant A. ; Phillips, Wayne A.
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2012-02, Vol.122 (2), p.553-557
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Select record 27
ArticlesPeer ReviewedFull Text
Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia
Author / Creator:Kentsis, Alex ; Reed, Casie ; Rice, Kim L ; Sanda, Takaomi ; Rodig, Scott J ; Tholouli, Eleni ; Christie, Amanda ; Valk, Peter J M ; Delwel, Ruud ; Ngo, Vu ; Kutok, Jeffery L ; Dahlberg, Suzanne E ; Moreau, Lisa A ; Byers, Richard J ; Christensen, James G ; Woude, George Vande ; Licht, Jonathan D ; Kung, Andrew L ; Staudt, Louis M ; Look, A Thomas
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2012-07, Vol.18 (7), p.1118-1122
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Select record 28
ArticlesPeer ReviewedFull Text
Phase I Study Evaluating Glesatinib (MGCD265), An Inhibitor of MET and AXL, in Patients with Non-small Cell Lung Cancer and Other Advanced Solid Tumors
Author / Creator:Kollmannsberger, Christian ; Hurwitz, Herbert ; Bazhenova, Lyudmila ; Cho, Byoung Chul ; Hong, David ; Park, Keunchil ; Reckamp, Karen L ; Sharma, Sunil ; Der-Torossian, Hirak ; Christensen, James G ; Faltaos, Demiana ; Potvin, Diane ; Tassell, Vanessa ; Chao, Richard ; Shapiro, Geoffrey I
Publisher:Paris: Springer Nature B.V
Journal title:Targeted oncology, 2023-01, Vol.18 (1), p.105-118
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Select record 29
ArticlesPeer ReviewedFull Text
Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation
Author / Creator:Jänne, Pasi A. ; Riely, Gregory J. ; Gadgeel, Shirish M. ; Heist, Rebecca S. ; Ou, Sai-Hong I. ; Pacheco, Jose M. ; Johnson, Melissa L. ; Sabari, Joshua K. ; Leventakos, Konstantinos ; Yau, Edwin ; Bazhenova, Lyudmila ; Negrao, Marcelo V. ; Pennell, Nathan A. ; Zhang, Jun ; Anderes, Kenna ; Der-Torossian, Hirak ; Kheoh, Thian ; Velastegui, Karen ; Yan, Xiaohong ; Christensen, James G. ; Chao, Richard C. ; Spira, Alexander I.
Publisher:United States
Journal title:The New England journal of medicine, 2022-07, Vol.387 (2), p.120-131
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Select record 30
ArticlesPeer ReviewedFull Text
Dose-escalation trial of the ALK, MET & ROS1 inhibitor, crizotinib, in patients with advanced cancer
Author / Creator:Clark, Jeffrey W ; Camidge, D Ross ; Kwak, Eunice L ; Maki, Robert G ; Shapiro, Geoffrey I ; Chen, Isan ; Tan, Weiwei ; Randolph, Sophia ; Christensen, James G ; Ozeck, Mark ; Tang, Yiyun ; Wilner, Keith D ; Salgia, Ravi
Publisher:London: Future Medicine Ltd
Journal title:Future oncology (London, England), 2020-01, Vol.16 (1), p.4289-4301
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Select record 31
ArticlesPeer ReviewedFull Text
Acquired Resistance to KRAS G12C Inhibition in Cancer
Author / Creator:Awad, Mark M. ; Liu, Shengwu ; Rybkin, Igor I. ; Arbour, Kathryn C. ; Dilly, Julien ; Zhu, Viola W. ; Johnson, Melissa L. ; Heist, Rebecca S. ; Patil, Tejas ; Riely, Gregory J. ; Jacobson, Joseph O. ; Yang, Xiaoping ; Persky, Nicole S. ; Root, David E. ; Lowder, Kristen E. ; Feng, Hanrong ; Zhang, Shannon S. ; Haigis, Kevin M. ; Hung, Yin P. ; Sholl, Lynette M. ; Wolpin, Brian M. ; Wiese, Julie ; Christiansen, Jason ; Lee, Jessica ; Schrock, Alexa B. ; Lim, Lee P. ; Garg, Kavita ; Li, Mark ; Engstrom, Lars D. ; Waters, Laura ; Lawson, J. David ; Olson, Peter ; Lito, Piro ; Ou, Sai-Hong I. ; Christensen, James G. ; Jänne, Pasi A. ; Aguirre, Andrew J.
Publisher:United States
Journal title:The New England journal of medicine, 2021-06, Vol.384 (25), p.2382-2393
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Select record 32
ArticlesPeer ReviewedFull Text
Synergistic Effect of the γ‐Secretase Inhibitor PF‐03084014 and Docetaxel in Breast Cancer Models
Author / Creator:Zhang, Cathy C. ; Yan, Zhengming ; Zong, Qing ; Fang, Douglas D. ; Painter, Cory ; Zhang, Qin ; Chen, Enhong ; Lira, Maruja E. ; John-Baptiste, Annette ; Christensen, James G.
Publisher:England: AlphaMed Press
Journal title:Stem cells translational medicine, 2013-03, Vol.2 (3), p.233-242
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Select record 33
ArticlesPeer ReviewedFull Text
Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models
Author / Creator:Cullinane, Carleen ; Dorow, Donna S ; Jackson, Susan ; Solomon, Benjamin ; Bogatyreva, Ekaterina ; Binns, David ; Young, Richard ; Arango, Maria E ; Christensen, James G ; McArthur, Grant A ; Hicks, Rodney J
Publisher:United States
Journal title:The Journal of nuclear medicine (1978), 2011-08, Vol.52 (8), p.1261
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Select record 34
ArticlesPeer ReviewedFull Text
Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in KrasG12D-LSL mice
Author / Creator:Simmons, Brett H. ; Lee, Joseph H. ; Lalwani, Kush ; Giddabasappa, Anand ; Snider, Brittany A. ; Wong, Anthony ; Lappin, Patrick B. ; Eswaraka, Jeetendra ; Kan, Julie L. ; Christensen, James G. ; Shojaei, Farbod
Publisher:Berlin/Heidelberg: Springer-Verlag
Journal title:Cancer chemotherapy and pharmacology, 2012-08, Vol.70 (2), p.213-220
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Select record 35
ArticlesPeer ReviewedFull Text
The KRASG12D inhibitor MRTX1133 elucidates KRAS-mediated oncogenesis
Publisher:New York: Nature Publishing Group
Journal title:Nature medicine, 2022-10, Vol.28 (10), p.2017-2018
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Select record 36
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Correction: A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation
Author / Creator:Lee, Nathan V. ; Lira, Maruja E. ; Pavlicek, Adam ; Ye, Jingjing ; Buckman, Dana ; Bagrodia, Shubha ; Srinivasa, Sreesha P. ; Zhao, Yongjun ; Aparicio, Samuel ; Rejto, Paul A. ; Christensen, James G. ; Ching, Keith A.
Publisher:San Francisco: Public Library of Science
Journal title:PloS one, 2012-08, Vol.7 (8)
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Select record 37
ArticlesPeer ReviewedFull Text
Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by 18F-FDG Small-Animal PET
Author / Creator:Tseng, Jeffrey R ; Kang, Keon Wook ; Dandekar, Mangal ; Yaghoubi, Shahriar ; Lee, Joseph H ; Christensen, James G ; Muir, Stephen ; Vincent, Patrick W ; Michaud, Neil R ; Gambhir, Sanjiv S
Publisher:United States: Soc Nuclear Med
Journal title:The Journal of nuclear medicine (1978), 2008-01, Vol.49 (1), p.129-134
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Select record 38
ArticlesFull Text
Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma
Author / Creator:Li, Zhuxuan ; Zhuang, Xueqian ; Pan, Chun-Hao ; Yan, Yan ; Thummalapalli, Rohit ; Hallin, Jill ; Torborg, Stefan ; Singhal, Anupriya ; Chang, Jason C ; Manchado, Eusebio ; Dow, Lukas E ; Yaeger, Rona ; Christensen, James G ; Lowe, Scott W ; Rudin, Charles M ; Joost, Simon ; Tammela, Tuomas
Publisher:Cold Spring Harbor Laboratory
Journal title:bioRxiv, 2023-10
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Select record 39
ArticlesPeer ReviewedFull Text
A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation
Author / Creator:Lee, Nathan V ; Lira, Maruja E ; Pavlicek, Adam ; Ye, Jingjing ; Buckman, Dana ; Bagrodia, Shubha ; Srinivasa, Sreesha P ; Zhao, Yongjun ; Aparicio, Samuel ; Rejto, Paul A ; Christensen, James G ; Ching, Keith A
Publisher:United States: Public Library of Science (PLoS)
Journal title:PloS one, 2012, Vol.7 (6), p.e39653
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Select record 40
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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer
Author / Creator:Nair, Amritha ; Chung, Hsiang-Ching ; Sun, Tingting ; Tyagi, Siddhartha ; Dobrolecki, Lacey E ; Dominguez-Vidana, Rocio ; Kurley, Sarah J ; Orellana, Mayra ; Renwick, Alexander ; Henke, David M ; Katsonis, Panagiotis ; Schmitt, Earlene ; Chan, Doug W ; Li, Hui ; Mao, Sufeng ; Petrovic, Ivana ; Creighton, Chad J ; Gutierrez, Carolina ; Dubrulle, Julien ; Stossi, Fabio ; Tyner, Jeffrey W ; Lichtarge, Olivier ; Lin, Charles Y ; Zhang, Bing ; Scott, Kenneth L ; Hilsenbeck, Susan G ; Sun, Jinpeng ; Yu, Xiao ; Osborne, C Kent ; Schiff, Rachel ; Christensen, James G ; Shields, David J ; Rimawi, Mothaffar F ; Ellis, Matthew J ; Shaw, Chad A ; Lewis, Michael T ; Westbrook, Thomas F
Publisher:New York: Springer New York
Journal title:Nature medicine, 2018-04, Vol.24 (4), p.505-511
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Crizotinib in ROS1-Rearranged Non–Small-Cell Lung Cancer

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The class I/IV HDAC inhibitor mocetinostat increases tumor antigen presentation, decreases immune suppressive cell types and augments checkpoint inhibitor therapy

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Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

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Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor

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Acquired Resistance to Crizotinib from a Mutation in CD74–ROS1

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An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice

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Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

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Phase I Study Evaluating Glesatinib (MGCD265), An Inhibitor of MET and AXL, in Patients with Non-small Cell Lung Cancer and Other Advanced Solid Tumors

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Adagrasib in Non–Small-Cell Lung Cancer Harboring a KRAS G12C Mutation

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Dose-escalation trial of the ALK, MET & ROS1 inhibitor, crizotinib, in patients with advanced cancer

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Acquired Resistance to KRAS G12C Inhibition in Cancer

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Synergistic Effect of the γ‐Secretase Inhibitor PF‐03084014 and Docetaxel in Breast Cancer Models

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Differential (18)F-FDG and 3'-deoxy-3'-(18)F-fluorothymidine PET responses to pharmacologic inhibition of the c-MET receptor in preclinical tumor models

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Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in KrasG12D-LSL mice

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The KRASG12D inhibitor MRTX1133 elucidates KRAS-mediated oncogenesis

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Correction: A Novel SND1-BRAF Fusion Confers Resistance to c-Met Inhibitor PF-04217903 in GTL16 Cells though MAPK Activation

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Preclinical Efficacy of the c-Met Inhibitor CE-355621 in a U87 MG Mouse Xenograft Model Evaluated by 18F-FDG Small-Animal PET

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Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

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A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation

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Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer

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