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1,218 results for Gene+Targeting+-+methods

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Select record 21
ArticlesPeer ReviewedFull Text
Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging
Author / Creator:Rhee, Hyun-Woo ; Zou, Peng ; Udeshi, Namrata D. ; Martell, Jeffrey D. ; Mootha, Vamsi K. ; Carr, Steven A. ; Ting, Alice Y.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-03, Vol.339 (6125), p.1328-1331
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ArticlesPeer ReviewedFull Text
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation
Author / Creator:Horlbeck, Max A ; Gilbert, Luke A ; Villalta, Jacqueline E ; Adamson, Britt ; Pak, Ryan A ; Chen, Yuwen ; Fields, Alexander P ; Park, Chong Yon ; Corn, Jacob E ; Kampmann, Martin ; Weissman, Jonathan S
Publisher:England: eLife Sciences Publications Ltd
Journal title:eLife, 2016-09, Vol.5
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ArticlesPeer ReviewedFull Text
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
Author / Creator:Stemmer, Manuel ; Thumberger, Thomas ; Del Sol Keyer, Maria ; Wittbrodt, Joachim ; Mateo, Juan L
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-04, Vol.10 (4), p.e0124633
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ArticlesPeer ReviewedFull Text
High levels of AAV vector integration into CRISPR-induced DNA breaks
Author / Creator:Hanlon, Killian S. ; Kleinstiver, Benjamin P. ; Garcia, Sara P. ; Zaborowski, Mikołaj P. ; Volak, Adrienn ; Spirig, Stefan E. ; Muller, Alissa ; Sousa, Alexander A. ; Tsai, Shengdar Q. ; Bengtsson, Niclas E. ; Lööv, Camilla ; Ingelsson, Martin ; Chamberlain, Jeffrey S. ; Corey, David P. ; Aryee, Martin J. ; Joung, J. Keith ; Breakefield, Xandra O. ; Maguire, Casey A. ; György, Bence
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2019-09, Vol.10 (1), p.4439-11, Article 4439
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Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila
Author / Creator:Yu, Zhongsheng ; Ren, Mengda ; Wang, Zhanxiang ; Zhang, Bo ; Rong, Yikang S ; Jiao, Renjie ; Gao, Guanjun
Publisher:United States: Genetics Society of America
Journal title:Genetics (Austin), 2013-09, Vol.195 (1), p.289-291
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Genome-wide inactivation of porcine endogenous retroviruses (PERVs)
Author / Creator:Yang, Luhan ; Güell, Marc ; Niu, Dong ; George, Haydy ; Lesha, Emal ; Grishin, Dennis ; Aach, John ; Shrock, Ellen ; Xu, Weihong ; Poci, Jürgen ; Cortazio, Rebeca ; Wilkinson, Robert A. ; Fishman, Jay A. ; Church, George
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2015-11, Vol.350 (6264), p.1101-1104
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ArticlesPeer ReviewedFull Text
CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo
Author / Creator:Moreno-Mateos, Miguel A ; Vejnar, Charles E ; Beaudoin, Jean-Denis ; Fernandez, Juan P ; Mis, Emily K ; Khokha, Mustafa K ; Giraldez, Antonio J
Publisher:New York: Nature Publishing Group US
Journal title:Nature methods, 2015-10, Vol.12 (10), p.982-988
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Improved tools to study astrocytes
Author / Creator:Yu, Xinzhu ; Nagai, Jun ; Khakh, Baljit S.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Neuroscience, 2020-03, Vol.21 (3), p.121-138
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Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease
Author / Creator:Kuscu, Cem ; Arslan, Sevki ; Singh, Ritambhara ; Thorpe, Jeremy ; Adli, Mazhar
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2014-07, Vol.32 (7), p.677-683
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Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA
Author / Creator:Long, Chengzu ; McAnally, John R. ; Shelton, John M. ; Mireault, Alex A. ; Bassel-Duby, Rhonda ; Olson, Eric N.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2014-09, Vol.345 (6201), p.1184-1188
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The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes
Author / Creator:Zhang, Donglei ; Tu, Shikui ; Stubna, Michael ; Wu, Wei-Sheng ; Huang, Wei-Che ; Weng, Zhiping ; Lee, Heng-Chi
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2018-02, Vol.359 (6375), p.587-592
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ArticlesPeer ReviewedFull Text
RNA-Guided Human Genome Engineering via Cas9
Author / Creator:Mali, Prashant ; Yang, Luhan ; Esvelt, Kevin M. ; Aach, John ; Guell, Marc ; DiCarlo, James E. ; Norville, Julie E. ; Church, George M.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-02, Vol.339 (6121), p.823-826
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ArticlesPeer ReviewedFull Text
Genetic improvement of tomato by targeted control of fruit softening
Author / Creator:Uluisik, Selman ; Chapman, Natalie H ; Smith, Rebecca ; Poole, Mervin ; Adams, Gary ; Gillis, Richard B ; Besong, Tabot M D ; Sheldon, Judith ; Stiegelmeyer, Suzy ; Perez, Laura ; Samsulrizal, Nurul ; Wang, Duoduo ; Fisk, Ian D ; Yang, Ni ; Baxter, Charles ; Rickett, Daniel ; Fray, Rupert ; Blanco-Ulate, Barbara ; Powell, Ann L T ; Harding, Stephen E ; Craigon, Jim ; Rose, Jocelyn K C ; Fich, Eric A ; Sun, Li ; Domozych, David S ; Fraser, Paul D ; Tucker, Gregory A ; Grierson, Don ; Seymour, Graham B
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2016-09, Vol.34 (9), p.950-952
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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
Author / Creator:Morgens, David W. ; Wainberg, Michael ; Boyle, Evan A. ; Ursu, Oana ; Araya, Carlos L. ; Tsui, C. Kimberly ; Haney, Michael S. ; Hess, Gaelen T. ; Han, Kyuho ; Jeng, Edwin E. ; Li, Amy ; Snyder, Michael P. ; Greenleaf, William J. ; Kundaje, Anshul ; Bassik, Michael C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-05, Vol.8 (1), p.15178-8, Article 15178
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Targeted genome modification of crop plants using a CRISPR-Cas system
Author / Creator:Shan, Qiwei ; Wang, Yanpeng ; Li, Jun ; Zhang, Yi ; Chen, Kunling ; Liang, Zhen ; Zhang, Kang ; Liu, Jinxing ; Xi, Jianzhong Jeff ; Qiu, Jin-Long ; Gao, Caixia
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2013-08, Vol.31 (8), p.686-688
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Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
Author / Creator:Li, Dali ; Qiu, Zhongwei ; Shao, Yanjiao ; Chen, Yuting ; Guan, Yuting ; Liu, Meizhen ; Li, Yongmei ; Gao, Na ; Wang, Liren ; Lu, Xiaoling ; Zhao, Yongxiang ; Liu, Mingyao
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2013-08, Vol.31 (8), p.681-683
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Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage
Author / Creator:Zhang, Jian-Ping ; Li, Xiao-Lan ; Li, Guo-Hua ; Chen, Wanqiu ; Arakaki, Cameron ; Botimer, Gary D ; Baylink, David ; Zhang, Lu ; Wen, Wei ; Fu, Ya-Wen ; Xu, Jing ; Chun, Noah ; Yuan, Weiping ; Cheng, Tao ; Zhang, Xiao-Bing
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2017-02, Vol.18 (1), p.35-35, Article 35
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A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi
Author / Creator:Nødvig, Christina S ; Nielsen, Jakob B ; Kogle, Martin E ; Mortensen, Uffe H
Publisher:United States: Public Library of Science
Journal title:PloS one, 2015-07, Vol.10 (7), p.e0133085
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ArticlesPeer ReviewedFull Text
Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR
Author / Creator:Li, Wei ; Köster, Johannes ; Xu, Han ; Chen, Chen-Hao ; Xiao, Tengfei ; Liu, Jun S ; Brown, Myles ; Liu, X Shirley
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2015-12, Vol.16 (1), p.281-281, Article 281
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Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems
Author / Creator:Li, Wei ; Teng, Fei ; Li, Tianda ; Zhou, Qi
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2013-08, Vol.31 (8), p.684-686
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Proteomic Mapping of Mitochondria in Living Cells via Spatially Restricted Enzymatic Tagging

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Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation

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CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool

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High levels of AAV vector integration into CRISPR-induced DNA breaks

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Highly efficient genome modifications mediated by CRISPR/Cas9 in Drosophila

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Genome-wide inactivation of porcine endogenous retroviruses (PERVs)

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CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

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Improved tools to study astrocytes

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Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease

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Prevention of muscular dystrophy in mice by CRISPR/Cas9–mediated editing of germline DNA

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The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes

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RNA-Guided Human Genome Engineering via Cas9

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Genetic improvement of tomato by targeted control of fruit softening

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Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens

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Targeted genome modification of crop plants using a CRISPR-Cas system

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Heritable gene targeting in the mouse and rat using a CRISPR-Cas system

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Efficient precise knockin with a double cut HDR donor after CRISPR/Cas9-mediated double-stranded DNA cleavage

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A CRISPR-Cas9 System for Genetic Engineering of Filamentous Fungi

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Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR

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Simultaneous generation and germline transmission of multiple gene mutations in rat using CRISPR-Cas systems

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