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94 results for Kusuhara,+Hiroyuki

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Select record 21
ArticlesPeer ReviewedFull Text
Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure
Author / Creator:Tsuboya Ayako ; Kubota Yutaro ; Ishida Hiroo ; Ohkuma Ryotaro ; Ishiguro Tomoyuki ; Hirasawa Yuya ; Ariizumi Hirotsugu ; Tsunoda Takuya ; Sasaki Yasutsuna ; Matsumoto Natsumi ; Kondo Yusuke ; Tomoda Yukana ; Kusuhara Hiroyuki ; Fujita Ken-ichi
Publisher:Heidelberg: Springer Nature B.V
Journal title:Cancer chemotherapy and pharmacology, 2021-09, Vol.88 (3), p.543-553
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Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis
Author / Creator:Tamura, Ryutaro ; Sabu, Yusuke ; Mizuno, Tadahaya ; Mizuno, Seiya ; Nakano, Satoshi ; Suzuki, Mitsuyoshi ; Abukawa, Daiki ; Kaji, Shunsaku ; Azuma, Yoshihiro ; Inui, Ayano ; Okamoto, Tatsuya ; Shimizu, Seiichi ; Fukuda, Akinari ; Sakamoto, Seisuke ; Kasahara, Mureo ; Takahashi, Satoru ; Kusuhara, Hiroyuki ; Zen, Yoh ; Ando, Tomohiro ; Hayashi, Hisamitsu
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-11, Vol.14 (1), p.6763-15, Article 6763
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PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3
Author / Creator:Yoshikado, Takashi ; Toshimoto, Kota ; Maeda, Kazuya ; Kusuhara, Hiroyuki ; Kimoto, Emi ; Rodrigues, A. David ; Chiba, Koji ; Sugiyama, Yuichi
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2018-11, Vol.7 (11), p.739-747
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Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans
Author / Creator:Watanabe, Takao ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Boston: Springer US
Journal title:Journal of pharmacokinetics and pharmacodynamics, 2010-12, Vol.37 (6), p.575-590
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Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset
Author / Creator:Azuma, Iori ; Mizuno, Tadahaya ; Morita, Katsuhisa ; Suzuki, Yutaka ; Kusuhara, Hiroyuki
Publisher:England: Oxford University Press
Journal title:NAR genomics and bioinformatics, 2024-03, Vol.6 (1), p.lqad111
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ArticlesPeer ReviewedFull Text
Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines
Author / Creator:Imai, Satoki ; Kikuchi, Ryota ; Tsuruya, Yuri ; Naoi, Sotaro ; Nishida, Sho ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Boston: Springer US
Journal title:Pharmaceutical research, 2013-11, Vol.30 (11), p.2880-2890
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A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions
Author / Creator:Yoshikado, Takashi ; Maeda, Kazuya ; Furihata, Sawako ; Terashima, Hanano ; Nakayama, Takeshi ; Ishigame, Keiko ; Tsunemoto, Kazunobu ; Kusuhara, Hiroyuki ; Furihata, Ken-ichi ; Sugiyama, Yuichi
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2017-08, Vol.34 (8), p.1570-1583
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Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies
Author / Creator:Yoshikado, Takashi ; Aoki, Yasunori ; Mochizuki, Tatsuki ; Rodrigues, A. David ; Chiba, Koji ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Hoboken: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2022-10, Vol.11 (10), p.1341-1357
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Select record 29
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Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis
Author / Creator:Imagawa, Kazuo ; Hayashi, Hisamitsu ; Sabu, Yusuke ; Tanikawa, Ken ; Fujishiro, Jun ; Kajikawa, Daigo ; Wada, Hiroki ; Kudo, Toyoichiro ; Kage, Masayoshi ; Kusuhara, Hiroyuki ; Sumazaki, Ryo
Publisher:London: Nature Publishing Group
Journal title:Journal of human genetics, 2018-05, Vol.63 (5), p.569-577
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Select record 30
ArticlesPeer ReviewedFull Text
A microsensing system for the in vivo real-time detection of local drug kinetics
Author / Creator:Ogata, Genki ; Ishii, Yuya ; Asai, Kai ; Sano, Yamato ; Nin, Fumiaki ; Yoshida, Takamasa ; Higuchi, Taiga ; Sawamura, Seishiro ; Ota, Takeru ; Hori, Karin ; Maeda, Kazuya ; Komune, Shizuo ; Doi, Katsumi ; Takai, Madoka ; Findlay, Ian ; Kusuhara, Hiroyuki ; Einaga, Yasuaki ; Hibino, Hiroshi
Publisher:London: Nature Publishing Group UK
Journal title:Nature biomedical engineering, 2017-08, Vol.1 (8), p.654-666
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ArticlesPeer ReviewedFull Text
Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs
Author / Creator:Mochizuki, Tatsuki ; Aoki, Yasunori ; Yoshikado, Takashi ; Yoshida, Kenta ; Lai, Yurong ; Hirabayashi, Hideki ; Yamaura, Yoshiyuki ; Rockich, Kevin ; Taskar, Kunal ; Takashima, Tadayuki ; Chu, Xiaoyan ; Zamek‐Gliszczynski, Maciej J. ; Mao, Jialin ; Maeda, Kazuya ; Furihata, Kenichi ; Sugiyama, Yuichi ; Kusuhara, Hiroyuki
Publisher:United States: John Wiley & Sons, Inc
Journal title:Clinical and translational science, 2022-06, Vol.15 (6), p.1519-1531
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Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polype...
Author / Creator:Asaumi, Ryuta ; Menzel, Karsten ; Lee, Wooin ; Nunoya, Ken‐ichi ; Imawaka, Haruo ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2019-11, Vol.8 (11), p.845-857
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Select record 33
ArticlesPeer ReviewedFull Text
Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo
Author / Creator:Kuwahara, Hiroya ; Song, Jindong ; Shimoura, Takahiro ; Yoshida-Tanaka, Kie ; Mizuno, Tadahaya ; Mochizuki, Tatsuki ; Zeniya, Satoshi ; Li, Fuying ; Nishina, Kazutaka ; Nagata, Tetsuya ; Ito, Shingo ; Kusuhara, Hiroyuki ; Yokota, Takanori
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2018-03, Vol.8 (1), p.4377-12, Article 4377
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Select record 34
ArticlesPeer ReviewedFull Text
Investigation of Endogenous Compounds for Assessing the Drug Interactions in the Urinary Excretion Involving Multidrug and Toxin Extrusion Proteins
Author / Creator:Kato, Koji ; Mori, Haruyuki ; Kito, Tomoko ; Yokochi, Miyu ; Ito, Sumito ; Inoue, Katsuhisa ; Yonezawa, Atsushi ; Katsura, Toshiya ; Kumagai, Yuji ; Yuasa, Hiroaki ; Moriyama, Yoshinori ; Inui, Ken-ichi ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Boston: Springer US
Journal title:Pharmaceutical research, 2014-01, Vol.31 (1), p.136-147
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ArticlesPeer ReviewedFull Text
Model‐based meta‐analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism
Author / Creator:Sato, Hiromi ; Marutani, Rika ; Takaoka, Ryota ; Mori‐Fegan, Daniel ; Wang, Xinying ; Maeda, Kazuya ; Kusuhara, Hiroyuki ; Suzuki, Hiroshi ; Yoshioka, Hideki ; Hisaka, Akihiro
Publisher:United States: John Wiley & Sons, Inc
Journal title:CPT: pharmacometrics and systems pharmacology, 2023-08, Vol.12 (8), p.1132-1142
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Select record 36
ArticlesPeer ReviewedFull Text
Thioester‐Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single‐Molecule Enzyme Activities of Esterases with Specified Substrate Recognition
Author / Creator:Ukegawa, Tatsuya ; Komatsu, Toru ; Minoda, Mayano ; Matsumoto, Takuya ; Iwasaka, Takumi ; Mizuno, Tadahaya ; Tachibana, Ryo ; Sakamoto, Shingo ; Hanaoka, Kenjiro ; Kusuhara, Hiroyuki ; Honda, Kazufumi ; Watanabe, Rikiya ; Urano, Yasuteru
Publisher:Germany: John Wiley & Sons, Inc
Journal title:Advanced science, 2024-03, Vol.11 (10), p.e2306559-n/a
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ArticlesPeer ReviewedFull Text
Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice
Author / Creator:Kato, Koji ; Moriyama, Chihiro ; Ito, Naoki ; Zhang, Xuan ; Hachiuma, Kenji ; Hagima, Naoko ; Iwata, Katsuya ; Yamaguchi, Jun-ichi ; Maeda, Kazuya ; Ito, Kousei ; Suzuki, Hiroshi ; Sugiyama, Yuichi ; Kusuhara, Hiroyuki
Publisher:New York: Springer US
Journal title:Pharmaceutical research, 2015-07, Vol.32 (7), p.2192-2204
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Select record 38
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Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis
Author / Creator:Nakano, Satoshi ; Osaka, Shuhei ; Sabu, Yusuke ; Minowa, Kei ; Hirai, Saeko ; Kondou, Hiroki ; Kimura, Takeshi ; Azuma, Yoshihiro ; Watanabe, Satoshi ; Inui, Ayano ; Bessho, Kazuhiko ; Nakamura, Hidefumi ; Kusano, Hironori ; Nakazawa, Atsuko ; Tanikawa, Ken ; Kage, Masayoshi ; Shimizu, Toshiaki ; Kusuhara, Hiroyuki ; Zen, Yoh ; Suzuki, Mitsuyoshi ; Hayashi, Hisamitsu
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2019-11, Vol.9 (1), p.17075-12, Article 17075
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Select record 39
ArticlesPeer ReviewedFull Text
Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers
Author / Creator:Issey, Takehara ; Takashi, Yoshikado ; Keiko, Ishigame ; Daiki, Mori ; Ken-Ichi, Furihata ; Nobuaki, Watanabe ; Osamu, Ando ; Kazuya, Maeda ; Hiroyuki, Kusuhara ; Yuichi, Sugiyama
Publisher:New York: Springer Science and Business Media LLC
Journal title:Pharmaceutical Research, 2019-04, Vol.36 (4), p.55-2, Article 55
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Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse
Author / Creator:Kitamura, Yoshiaki ; Kusuhara, Hiroyuki ; Sugiyama, Yuichi
Publisher:Boston: Boston : Springer US
Journal title:Pharmaceutical research, 2010-04, Vol.27 (4), p.665-672
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Minimal contribution of the hepatic uptake transporter OATP1B1 to the inter-individual variability in SN-38 pharmacokinetics in cancer patients without severe renal failure

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Intestinal Atp8b1 dysfunction causes hepatic choline deficiency and steatohepatitis

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PBPK Modeling of Coproporphyrin I as an Endogenous Biomarker for Drug Interactions Involving Inhibition of Hepatic OATP1B1 and OATP1B3

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Application of physiologically based pharmacokinetic modeling and clearance concept to drugs showing transporter-mediated distribution and clearance in humans

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Investigation of the usefulness of liver-specific deconvolution method by establishing a liver benchmark dataset

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Epigenetic Regulation of Organic Anion Transporting Polypeptide 1B3 in Cancer Cell Lines

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A Clinical Cassette Dosing Study for Evaluating the Contribution of Hepatic OATPs and CYP3A to Drug-Drug Interactions

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Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies

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Clinical phenotype and molecular analysis of a homozygous ABCB11 mutation responsible for progressive infantile cholestasis

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A microsensing system for the in vivo real-time detection of local drug kinetics

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Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs

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Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polype...

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Modulation of blood-brain barrier function by a heteroduplex oligonucleotide in vivo

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Investigation of Endogenous Compounds for Assessing the Drug Interactions in the Urinary Excretion Involving Multidrug and Toxin Extrusion Proteins

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Model‐based meta‐analysis of ethnic differences and their variabilities in clearance of oral drugs classified by clearance mechanism

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Thioester‐Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single‐Molecule Enzyme Activities of Esterases with Specified Substrate Recognition

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Involvement of Organic Cation Transporters in the Clearance and Milk Secretion of Thiamine in Mice

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Effect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis

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Correction to: Comparative Study of the Dose-Dependence of OATP1B Inhibition by Rifampicin Using Probe Drugs and Endogenous Substrates in Healthy Volunteers

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Basolateral Efflux Mediated by Multidrug Resistance-Associated Protein 3 (Mrp3/Abcc3) Facilitates Intestinal Absorption of Folates in Mouse

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