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72 results for Lapatinib+-+pharmacology

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Select record 21
ArticlesPeer ReviewedFull Text
Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers
Author / Creator:Sun, Bowen ; Mason, Seth ; Wilson, Robert C. ; Hazard, Starr E. ; Wang, Yubao ; Fang, Rong ; Wang, Qiwei ; Yeh, Elizabeth S. ; Yang, Meixiang ; Roberts, Thomas M. ; Zhao, Jean J. ; Wang, Qi
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2020-01, Vol.39 (1), p.50-63
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Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation
Author / Creator:Yi, Yong ; Chen, Deshi ; Ao, Juan ; Zhang, Wenhua ; Yi, Jianqiao ; Ren, Xiaokun ; Fei, Junjie ; Li, Fengtian ; Niu, Mengmeng ; Chen, Hu ; Luo, Yangkun ; Luo, Zhijun ; Xiao, Zhi-Xiong Jim
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-04, Vol.117 (14), p.8013-8021
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Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells
Author / Creator:Fonseca-Alves, Carlos Eduardo ; Leis-Filho, Antonio Fernando ; Lacerda, Zara Alves ; de Faria Lainetti, Patricia ; Amorim, Renee Laufer ; Rogatto, Silvia Regina
Publisher:United States: Public Library of Science
Journal title:PloS one, 2024-04, Vol.19 (4), p.e0297043-e0297043
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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects
Author / Creator:Saul, Sirle ; Karim, Marwah ; Ghita, Luca ; Huang, Pei-Tzu ; Chiu, Winston ; Durán, Verónica ; Lo, Chieh-Wen ; Kumar, Sathish ; Bhalla, Nishank ; Leyssen, Pieter ; Alem, Farhang ; Boghdeh, Niloufar A. ; Tran, Do H.N. ; Cohen, Courtney A. ; Brown, Jacquelyn A. ; Huie, Kathleen E. ; Tindle, Courtney ; Sibai, Mamdouh ; Ye, Chengjin ; Khalil, Ahmed Magdy ; Chiem, Kevin ; Martinez-Sobrido, Luis ; Dye, John M. ; Pinsky, Benjamin A. ; Ghosh, Pradipta ; Das, Soumita ; Solow-Cordero, David E. ; Jin, Jing ; Wikswo, John P. ; Jochmans, Dirk ; Neyts, Johan ; De Jonghe, Steven ; Narayanan, Aarthi ; Einav, Shirit
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2023-10, Vol.133 (19), p.1-17
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Assessment of modelling strategies for drug response prediction in cell lines and xenografts
Author / Creator:Kurilov Roman ; Haibe-Kains Benjamin ; Brors Benedikt
Publisher:London: Nature Publishing Group
Journal title:Scientific reports, 2020-02, Vol.10 (1)
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Lapatinib ameliorates skin fibrosis by inhibiting TGF-β1/Smad and non-Smad signaling pathway
Author / Creator:Wang, Yongping ; Zhang, Tiantian ; Song, Hao ; Yang, Cheng
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.8444-17, Article 8444
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Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection
Author / Creator:Sornprasert, Suthatta ; Jaratsittisin, Janejira ; Chumchanchira, Chanida ; Smith, Duncan R.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2025-03, Vol.15 (1), p.10731-16, Article 10731
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HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies
Author / Creator:Tracey, Natasha ; Creedon, Helen ; Kemp, Alain J. ; Culley, Jayne ; Muir, Morwenna ; Klinowska, Teresa ; Brunton, Valerie G.
Publisher:New York: Springer US
Journal title:Breast cancer research and treatment, 2020-02, Vol.179 (3), p.543-555
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Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain
Author / Creator:Bhan, Arunoday ; Ansari, Khairul ; Chen, Mike Y ; Jandial, Rahul
Publisher:England: Nature Publishing Group UK
Journal title:Scientific reports, 2021-10, Vol.11 (1), p.16866
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Select record 30
ArticlesPeer ReviewedFull Text
Antioxidant functions of DHHC3 suppress anti-cancer drug activities
Publisher:Basel: Springer Nature B.V
Journal title:Cellular and molecular life sciences : CMLS, 2021-03, Vol.78 (5), p.2341-2353
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Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways
Author / Creator:Zervantonakis, Ioannis K. ; Poskus, Matthew D. ; Scott, Alexis L. ; Selfors, Laura M. ; Lin, Jia-Ren ; Dillon, Deborah A. ; Pathania, Shailja ; Sorger, Peter K. ; Mills, Gordon B. ; Brugg, Joan S.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2020-07, Vol.117 (28), p.16500-16508
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Select record 32
ArticlesPeer ReviewedFull Text
Lapatinib and poziotinib overcome ABCB1-mediated paclitaxel resistance in ovarian cancer
Author / Creator:McCorkle, J. Robert ; Gorski, Justin W. ; Liu, Jinpeng ; Riggs, McKayla B. ; McDowell, Anthony B. ; Lin, Nan ; Wang, Chi ; Ueland, Frederick R. ; Kolesar, Jill M.
Publisher:United States: Public Library of Science
Journal title:PloS one, 2021-08, Vol.16 (8), p.e0254205-e0254205
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Select record 33
ArticlesPeer ReviewedFull Text
Dual targeting micelles loaded with paclitaxel and lapatinib for combinational therapy of brain metastases from breast cancer
Author / Creator:Lu, Heng ; Chen, Tianran ; Wang, Yiran ; He, Yuwei ; Pang, Zhiqing ; Wang, Yajie
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-02, Vol.12 (1), p.2610-2610, Article 2610
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Select record 34
ArticlesPeer ReviewedFull Text
Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface
Author / Creator:Claus, Jeroen ; Patel, Gargi ; Autore, Flavia ; Colomba, Audrey ; Weitsman, Gregory ; Soliman, Tanya N ; Roberts, Selene ; Zanetti-Domingues, Laura C ; Hirsch, Michael ; Collu, Francesca ; George, Roger ; Ortiz-Zapater, Elena ; Barber, Paul R ; Vojnovic, Boris ; Yarden, Yosef ; Martin-Fernandez, Marisa L ; Cameron, Angus ; Fraternali, Franca ; Ng, Tony ; Parker, Peter J
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2018-05, Vol.7
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Select record 35
ArticlesPeer ReviewedFull Text
Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels
Author / Creator:Gibson, Spencer ; Konzelman, Carmen ; Blankstein, Anna R. ; Villalpando-Rodriguez, Gloria E.
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:Oxidative medicine and cellular longevity, 2019, Vol.2019 (2019), p.1-14
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Select record 36
ArticlesPeer ReviewedFull Text
Long noncoding RNA NONHSAT160169.1 promotes resistance via hsa-let-7c-3p/SOX2 axis in gastric cancer
Author / Creator:Zhao, Xuan ; Xu, Zijian ; Meng, Bi ; Ren, Tong ; Wang, Xu ; Hou, Rui ; Li, Sijin ; Ma, Wen ; Liu, Dan ; Zheng, Junnian ; Shi, Ming
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2023-11, Vol.13 (1), p.20858-20858, Article 20858
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Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer
Author / Creator:Kennedy, Sean P. ; O’Neill, Michael ; Cunningham, Darren ; Morris, Patrick G. ; Toomey, Sinead ; Blanco-Aparicio, Carmen ; Martinez, Sonia ; Pastor, Joaquin ; Eustace, Alex J. ; Hennessy, Bryan T.
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2020-04, Vol.39 (14), p.3028-3040
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A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling...
Author / Creator:Hamalian, Sarkis ; Güth, Robert ; Runa, Farhana ; Sanchez, Francesca ; Vickers, Eric ; Agajanian, Megan ; Molnar, Justin ; Nguyen, Tuan ; Gamez, Joshua ; Humphries, Jonathan D. ; Nayak, Anupma ; Humphries, Martin J. ; Tchou, Julia ; Zervantonakis, Ioannis K. ; Kelber, Jonathan A.
Publisher:London: Nature Publishing Group UK
Journal title:Oncogene, 2021-08, Vol.40 (33), p.5224-5235
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Select record 39
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High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer
Author / Creator:Normann, Lisa Svartdal ; Haugen, Mads Haugland ; Hongisto, Vesa ; Aure, Miriam Ragle ; Leivonen, Suvi-Katri ; Kristensen, Vessela N. ; Tahiri, Andliena ; Engebraaten, Olav ; Sahlberg, Kristine Kleivi ; Mælandsmo, Gunhild Mari
Publisher:United States: Public Library of Science
Journal title:PloS one, 2023-01, Vol.18 (1), p.e0280507
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Select record 40
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Lapatinib-Resistant HER2+ Breast Cancer Cells Are Associated with Dysregulation of MAPK and p70S6K/PDCD4 Pathways and Calcium Management, Influence of Cryptotanshinone
Author / Creator:Hernández-Valencia, Jorge ; García-Villarreal, Ruth ; Rodríguez-Jiménez, Manuel ; Hernández-Avalos, Alex Daniel ; Rivero, Ignacio A. ; Vique-Sánchez, José Luis ; Chimal-Vega, Brenda ; Pulido-Capiz, Angel ; García-González, Victor
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2025-04, Vol.26 (8), p.3763
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Showing 21 to 40 of 72 results

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Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers

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Transcriptional suppression of AMPKα1 promotes breast cancer metastasis upon oncogene activation

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Lapatinib antitumor effect is associated with PI3K and MAPK pathway: An analysis in human and canine prostate cancer cells

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Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects

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Assessment of modelling strategies for drug response prediction in cell lines and xenografts

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Lapatinib ameliorates skin fibrosis by inhibiting TGF-β1/Smad and non-Smad signaling pathway

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Effects of the fatty acid synthase inhibitors triclosan and lapatinib on dengue virus and Zika virus infection

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HO-1 drives autophagy as a mechanism of resistance against HER2-targeted therapies

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Human induced pluripotent stem cell-derived platelets loaded with lapatinib effectively target HER2+ breast cancer metastasis to the brain

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Antioxidant functions of DHHC3 suppress anti-cancer drug activities

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Fibroblast–tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways

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Lapatinib and poziotinib overcome ABCB1-mediated paclitaxel resistance in ovarian cancer

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Dual targeting micelles loaded with paclitaxel and lapatinib for combinational therapy of brain metastases from breast cancer

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Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

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Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

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Long noncoding RNA NONHSAT160169.1 promotes resistance via hsa-let-7c-3p/SOX2 axis in gastric cancer

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Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

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A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling...

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High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer

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Lapatinib-Resistant HER2+ Breast Cancer Cells Are Associated with Dysregulation of MAPK and p70S6K/PDCD4 Pathways and Calcium Management, Influence of Cryptotanshinone

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