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ArticlesPeer ReviewedFull Text
Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms
Author / Creator:Barlow, Adam D. ; Nicholson, Michael L. ; Herbert, Terry P.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2013-08, Vol.62 (8), p.2674-2682
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Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism
Author / Creator:Wang, Rong ; Yu, Zhen ; Sunchu, Bharath ; Shoaf, James ; Dang, Ivana ; Zhao, Stephanie ; Caples, Kelsey ; Bradley, Lynda ; Beaver, Laura M. ; Ho, Emily ; Löhr, Christiane V. ; Perez, Viviana I.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2017-06, Vol.16 (3), p.564-574
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Rapamycin rejuvenates oral health in aging mice
Author / Creator:An, Jonathan Y ; Kerns, Kristopher A ; Ouellette, Andrew ; Robinson, Laura ; Morris, H Douglas ; Kaczorowski, Catherine ; Park, So-Il ; Mekvanich, Title ; Kang, Alex ; McLean, Jeffrey S ; Cox, Timothy C ; Kaeberlein, Matt
Publisher:England: eLife Science Publications, Ltd
Journal title:eLife, 2020-04, Vol.9
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Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)—rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-C...
Author / Creator:Tunbridge, Matthew ; Perkins, Griffith B. ; Singer, Julian ; Salehi, Tania ; Ying, Tracey ; Grubor-Bauk, Branka ; Barry, Simon ; Sim, Beatrice ; Hissaria, Pravin ; Chadban, Steven J. ; Coates, P. Toby
Publisher:London: BioMed Central Ltd
Journal title:Current controlled trials in cardiovascular medicine, 2022-09, Vol.23 (1), p.780-780, Article 780
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Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects
Author / Creator:Strong, Randy ; Miller, Richard A. ; Bogue, Molly ; Fernandez, Elizabeth ; Javors, Martin A. ; Libert, Sergiy ; Marinez, Paul Anthony ; Murphy, Michael P. ; Musi, Nicolas ; Nelson, James F. ; Petrascheck, Michael ; Reifsnyder, Peter ; Richardson, Arlan ; Salmon, Adam B. ; Macchiarini, Francesca ; Harrison, David E.
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2020-11, Vol.19 (11), p.e13269-n/a
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Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration
Author / Creator:Meliani, Amine ; Boisgerault, Florence ; Hardet, Romain ; Marmier, Solenne ; Collaud, Fanny ; Ronzitti, Giuseppe ; Leborgne, Christian ; Costa Verdera, Helena ; Simon Sola, Marcelo ; Charles, Severine ; Vignaud, Alban ; van Wittenberghe, Laetitia ; Manni, Giorgia ; Christophe, Olivier ; Fallarino, Francesca ; Roy, Christopher ; Michaud, Alicia ; Ilyinskii, Petr ; Kishimoto, Takashi Kei ; Mingozzi, Federico
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-10, Vol.9 (1), p.4098-13, Article 4098
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Target of rapamycin signaling orchestrates growth–defense trade-offs in plants
Author / Creator:De Vleesschauwer, David ; Filipe, Osvaldo ; Hoffman, Gena ; Seifi, Hamed Soren ; Haeck, Ashley ; Canlas, Patrick ; Van Bockhaven, Jonas ; De Waele, Evelien ; Demeestere, Kristof ; Ronald, Pamela ; Hofte, Monica
Publisher:England: New Phytologist Trust
Journal title:The New phytologist, 2018-01, Vol.217 (1), p.305-319
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Use of sirolimus (rapamycin) to treat refractory Crohn’s disease
Author / Creator:Massey, D C O ; Bredin, F ; Parkes, M
Publisher:London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2008-09, Vol.57 (9), p.1294-1296
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Autophagy activation by rapamycin reduces severity of experimental osteoarthritis
Author / Creator:Caramés, Beatriz ; Hasegawa, Akihiko ; Taniguchi, Noboru ; Miyaki, Shigeru ; Blanco, Francisco J ; Lotz, Martin
Publisher:London: BMJ Publishing Group Ltd and European League Against Rheumatism
Journal title:Annals of the rheumatic diseases, 2012-04, Vol.71 (4), p.575-581
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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease
Author / Creator:Spilman, Patricia ; Podlutskaya, Natalia ; Hart, Matthew J. ; Debnath, Jayanta ; Gorostiza, Olivia ; Bredesen, Dale ; Richardson, Arlan ; Strong, Randy ; Galvan, Veronica
Publisher:United States: Public Library of Science
Journal title:PloS one, 2010-04, Vol.5 (4), p.e9979
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Late‐life rapamycin treatment reverses age‐related heart dysfunction
Author / Creator:Flynn, James M. ; O'Leary, Monique N. ; Zambataro, Christopher A. ; Academia, Emmeline C. ; Presley, Michael P. ; Garrett, Brittany J. ; Zykovich, Artem ; Mooney, Sean D. ; Strong, Randy ; Rosen, Clifford J. ; Kapahi, Pankaj ; Nelson, Michael D. ; Kennedy, Brian K. ; Melov, Simon
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2013-10, Vol.12 (5), p.851-862
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Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin
Author / Creator:Gan, Ninghai ; Han, Yan ; Zeng, Weizhong ; Wang, Yan ; Xue, Jing ; Jiang, Youxing
Publisher:United States
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2022-02, Vol.119 (7)
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ArticlesPeer ReviewedFull Text
Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Author / Creator:Miller, Richard A. ; Harrison, David E. ; Astle, Clinton M. ; Fernandez, Elizabeth ; Flurkey, Kevin ; Han, Melissa ; Javors, Martin A. ; Li, Xinna ; Nadon, Nancy L. ; Nelson, James F. ; Pletcher, Scott ; Salmon, Adam B. ; Sharp, Zelton Dave ; Van Roekel, Sabrina ; Winkleman, Lynn ; Strong, Randy
Publisher:England: John Wiley & Sons, Inc
Journal title:Aging cell, 2014-06, Vol.13 (3), p.468-477
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ArticlesPeer ReviewedFull Text
mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
Author / Creator:Kang, Seong A. ; Pacold, Michael E. ; Cervantes, Christopher L. ; Lim, Daniel ; Lou, Hua Jane ; Ottina, Kathleen ; Gray, Nathanael S. ; Turk, Benjamin E. ; Yaffe, Michael B. ; Sabatini, David M.
Publisher:United States: American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2013-07, Vol.341 (6144), p.364-364
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Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin
Author / Creator:Abdallah, Chadi G. ; Averill, Lynnette A. ; Gueorguieva, Ralitza ; Goktas, Selin ; Purohit, Prerana ; Ranganathan, Mohini ; Sherif, Mohamed ; Ahn, Kyung-Heup ; D’Souza, Deepak Cyril ; Formica, Richard ; Southwick, Steven M. ; Duman, Ronald S. ; Sanacora, Gerard ; Krystal, John H.
Publisher:England: Nature Publishing Group
Journal title:Neuropsychopharmacology (New York, N.Y.), 2020-05, Vol.45 (6), p.990-997
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Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function
Author / Creator:Long, S. Alice ; Rieck, Mary ; Sanda, Srinath ; Bollyky, Jennifer B. ; Samuels, Peter L. ; Goland, Robin ; Ahmann, Andrew ; Rabinovitch, Alex ; Aggarwal, Sudeepta ; Phippard, Deborah ; Turka, Laurence A. ; Ehlers, Mario R. ; Bianchine, Peter J. ; Boyle, Karen D. ; Adah, Steven A. ; Bluestone, Jeffrey A. ; Buckner, Jane H. ; Greenbaum, Carla J.
Publisher:Alexandria, VA: American Diabetes Association
Journal title:Diabetes (New York, N.Y.), 2012-09, Vol.61 (9), p.2340-2348
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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease
Author / Creator:Panwar, Vivek ; Singh, Aishwarya ; Bhatt, Manini ; Tonk, Rajiv K. ; Azizov, Shavkatjon ; Raza, Agha Saquib ; Sengupta, Shinjinee ; Kumar, Deepak ; Garg, Manoj
Publisher:London: Nature Publishing Group UK
Journal title:Signal transduction and targeted therapy, 2023-10, Vol.8 (1), p.375-375, Article 375
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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Author / Creator:Harrison, David E. ; Strong, Randy ; Sharp, Zelton Dave ; Nelson, James F. ; Astle, Clinton M. ; Flurkey, Kevin ; Nadon, Nancy L. ; Wilkinson, J. Erby ; Frenkel, Krystyna ; Carter, Christy S. ; Pahor, Marco ; Javors, Martin A. ; Fernandez, Elizabeth ; Miller, Richard A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2009-07, Vol.460 (7253), p.392-395
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Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response
Author / Creator:Li, Xiaomin ; Chen, Dongmei ; Xia, Wei ; Bu, Lin ; Shi, Yuanfeng ; Wang, Yanli ; Sun, Yan ; Chen, Xiaobing ; Zhuo, Luo ; Han, Jiayan
Publisher:Cairo, Egypt: Hindawi Publishing Corporation
Journal title:BioMed research international, 2020, Vol.2020 (2020), p.1-9
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Why Is Rapamycin Not a Rapalog?
Author / Creator:Kuerec, Ajla Hodzic ; Maier, Andrea B.
Publisher:Basel, Switzerland: S. Karger AG
Journal title:Gerontology (Basel), 2023-06, Vol.69 (6), p.657-659
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Evidence for Rapamycin Toxicity in Pancreatic β-Cells and a Review of the Underlying Molecular Mechanisms

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Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2‐independent mechanism

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Rapamycin rejuvenates oral health in aging mice

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Rapamycin and inulin for booster vaccine response stimulation (RIVASTIM)—rapamycin: study protocol for a randomised, controlled trial of immunosuppression modification with rapamycin to improve SARS-C...

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Rapamycin‐mediated mouse lifespan extension: Late‐life dosage regimes with sex‐specific effects

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Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

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Target of rapamycin signaling orchestrates growth–defense trade-offs in plants

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Use of sirolimus (rapamycin) to treat refractory Crohn’s disease

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Autophagy activation by rapamycin reduces severity of experimental osteoarthritis

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

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Late‐life rapamycin treatment reverses age‐related heart dysfunction

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Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin

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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

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mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

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Modulation of the antidepressant effects of ketamine by the mTORC1 inhibitor rapamycin

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Rapamycin/IL-2 Combination Therapy in Patients With Type 1 Diabetes Augments Tregs yet Transiently Impairs β-Cell Function

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Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Rapamycin Inhibited Pyroptosis and Reduced the Release of IL-1β and IL-18 in the Septic Response

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Why Is Rapamycin Not a Rapalog?

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