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73 results for van+Deursen,+Jan+M.

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Select record 21
ArticlesPeer ReviewedFull Text
Senescent cells limit p53 activity via multiple mechanisms to remain viable
Author / Creator:Sturmlechner, Ines ; Sine, Chance C. ; Jeganathan, Karthik B. ; Zhang, Cheng ; Fierro Velasco, Raul O. ; Baker, Darren J. ; Li, Hu ; van Deursen, Jan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-06, Vol.13 (1), p.3722-3722, Article 3722
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ArticlesPeer ReviewedFull Text
Lack of Acrosome Formation in Hrb-Deficient Mice
Author / Creator:Kang-Decker, Ningling ; Mantchev, George T. ; Juneja, Subhash C. ; McNiven, Mark A. ; Jan M. A. van Deursen
Publisher:Washington, DC: American Society for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2001-11, Vol.294 (5546), p.1531-1533
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ArticlesPeer ReviewedFull Text
Reprogramming to pluripotency can conceal somatic cell chromosomal instability
Author / Creator:Hamada, Masakazu ; Malureanu, Liviu A ; Wijshake, Tobias ; Zhou, Wei ; van Deursen, Jan M
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2012-08, Vol.8 (8), p.e1002913-e1002913
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ArticlesPeer ReviewedFull Text
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
Author / Creator:Baker, Darren J. ; Dawlaty, Meelad M. ; Wijshake, Tobias ; Jeganathan, Karthik B. ; Malureanu, Liviu ; van Ree, Janine H. ; Crespo-Diaz, Ruben ; Reyes, Santiago ; Seaburg, Lauren ; Shapiro, Virginia ; Behfar, Atta ; Terzic, Andre ; van de Sluis, Bart ; van Deursen, Jan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature cell biology, 2013-01, Vol.15 (1), p.96-102
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ArticlesPeer ReviewedFull Text
ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis
Author / Creator:Li, Min ; Fang, Xiao ; Baker, Darren J ; Guo, Linjie ; Gao, Xue ; Wei, Zhubo ; Han, Shuhua ; van Deursen, Jan M ; Zhang, Pumin
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (32), p.14188-14193
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ArticlesPeer ReviewedFull Text
Spartan deficiency causes genomic instability and progeroid phenotypes
Author / Creator:Maskey, Reeja S. ; Kim, Myoung Shin ; Baker, Darren J. ; Childs, Bennett ; Malureanu, Liviu A. ; Jeganathan, Karthik B. ; Machida, Yuka ; van Deursen, Jan M. ; Machida, Yuichi J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2014-12, Vol.5 (1), p.5744-5744, Article 5744
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Select record 27
ArticlesPeer ReviewedFull Text
Hyperphosphorylated PTEN exerts oncogenic properties
Author / Creator:van Ree, Janine H. ; Jeganathan, Karthik B. ; Fierro Velasco, Raul O. ; Zhang, Cheng ; Can, Ismail ; Hamada, Masakazu ; Li, Hu ; Baker, Darren J. ; van Deursen, Jan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-05, Vol.14 (1), p.2983-2983, Article 2983
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ArticlesPeer ReviewedFull Text
The role of senescent cells in ageing
Author / Creator:van Deursen, Jan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2014-05, Vol.509 (7501), p.439-446
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ArticlesPeer ReviewedFull Text
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy
Author / Creator:Naylor, Ryan M ; Jeganathan, Karthik B ; Cao, Xiuqi ; van Deursen, Jan M
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2016-02, Vol.126 (2), p.543-559
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Select record 30
ArticlesPeer ReviewedFull Text
Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I
Author / Creator:El Yakoubi, Warif ; Buffin, Eulalie ; Cladière, Damien ; Gryaznova, Yulia ; Berenguer, Inés ; Touati, Sandra A. ; Gómez, Rocío ; Suja, José A. ; van Deursen, Jan M. ; Wassmann, Katja
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2017-09, Vol.8 (1), p.694-14, Article 694
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ArticlesPeer ReviewedFull Text
Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation
Author / Creator:Kanakkanthara, Arun ; Jeganathan, Karthik B ; Limzerwala, Jazeel F ; Baker, Darren J ; Hamada, Masakazu ; Nam, Hyun-Ja ; van Deursen, Willemijn H ; Hamada, Naomi ; Naylor, Ryan M ; Becker, Nicole A ; Davies, Brian A ; van Ree, Janine H ; Mer, Georges ; Shapiro, Virginia S ; Maher, 3rd, L James ; Katzmann, David J ; van Deursen, Jan M
Publisher:United States: The American Association for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 2016-09, Vol.353 (6307), p.1549-1552
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Select record 32
ArticlesPeer ReviewedFull Text
BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome
Author / Creator:Sieben, Cynthia J ; Jeganathan, Karthik B ; Nelson, Grace G ; Sturmlechner, Ines ; Zhang, Cheng ; van Deursen, Willemijn H ; Bakker, Bjorn ; Foijer, Floris ; Li, Hu ; Baker, Darren J ; van Deursen, Jan M
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2020-01, Vol.130 (1), p.171-188
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Select record 33
ArticlesPeer ReviewedFull Text
ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage
Author / Creator:Nowsheen, Somaira ; Aziz, Khaled ; Luo, Kuntian ; Deng, Min ; Qin, Bo ; Yuan, Jian ; Jeganathan, Karthik B. ; Yu, Jia ; Zhang, Henan ; Ding, Wei ; van Deursen, Jan M. ; Lou, Zhenkun
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-07, Vol.9 (1), p.2736-11, Article 2736
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Select record 34
ArticlesPeer ReviewedFull Text
Cdc20 is critical for meiosis I and fertility of female mice
Author / Creator:Jin, Fang ; Hamada, Masakazu ; Malureanu, Liviu ; Jeganathan, Karthik B ; Zhou, Wei ; Morbeck, Dean E ; van Deursen, Jan M
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2010-09, Vol.6 (9), p.e1001147-e1001147
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Select record 35
ArticlesPeer ReviewedFull Text
Senescent cells: a therapeutic target for cardiovascular disease
Author / Creator:Childs, Bennett G ; Li, Hu ; van Deursen, Jan M
Publisher:United States: American Society for Clinical Investigation
Journal title:The Journal of clinical investigation, 2018-04, Vol.128 (4), p.1217-1228
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Select record 36
ArticlesPeer ReviewedFull Text
Defective Lymphoid Development in Mice Lacking Jak3
Author / Creator:Nosaka, Tetsuya ; Jan M. A. van Deursen ; Tripp, Ralph A. ; Thierfelder, William E. ; Witthuhn, Bruce A. ; McMickle, Anthony P. ; Doherty, Peter C. ; Grosveld, Gerard C. ; Ihle, James N.
Publisher:Washington, DC: American Society for the Advancement of Science
Journal title:Science (American Association for the Advancement of Science), 1995-11, Vol.270 (5237), p.800-802
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Select record 37
ArticlesPeer ReviewedFull Text
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
Author / Creator:Bussian, Tyler J. ; Aziz, Asef ; Meyer, Charlton F. ; Swenson, Barbara L. ; van Deursen, Jan M. ; Baker, Darren J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2018-10, Vol.562 (7728), p.578-582
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Senescent cells: an emerging target for diseases of ageing
Author / Creator:Childs, Bennett G. ; Gluscevic, Martina ; Baker, Darren J. ; Laberge, Remi-Martin ; Marquess, Dan ; Dananberg, Jamie ; van Deursen, Jan M.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2017-10, Vol.16 (10), p.718-735
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Select record 39
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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Author / Creator:Jeon, Ok Hee ; Kim, Chaekyu ; Laberge, Remi-Martin ; Demaria, Marco ; Rathod, Sona ; Vasserot, Alain P ; Chung, Jae Wook ; Kim, Do Hun ; Poon, Yan ; David, Nathaniel ; Baker, Darren J ; van Deursen, Jan M ; Campisi, Judith ; Elisseeff, Jennifer H
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-06, Vol.23 (6), p.775-781
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Select record 40
ArticlesPeer ReviewedFull Text
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
Author / Creator:Baker, Darren J ; Childs, Bennett G ; Durik, Matej ; Wijers, Melinde E ; Sieben, Cynthia J ; Zhong, Jian ; Saltness, Rachel A ; Jeganathan, Karthik B ; Verzosa, Grace Casaclang ; Pezeshki, Abdulmohammad ; Khazaie, Khashayarsha ; Miller, Jordan D ; van Deursen, Jan M
Publisher:England
Journal title:Nature (London), 2016-02, Vol.530 (7589), p.184-189
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Senescent cells limit p53 activity via multiple mechanisms to remain viable

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Lack of Acrosome Formation in Hrb-Deficient Mice

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Reprogramming to pluripotency can conceal somatic cell chromosomal instability

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Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan

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ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

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Spartan deficiency causes genomic instability and progeroid phenotypes

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Hyperphosphorylated PTEN exerts oncogenic properties

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The role of senescent cells in ageing

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Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy

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Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I

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Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation

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BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome

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ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage

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Cdc20 is critical for meiosis I and fertility of female mice

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Senescent cells: a therapeutic target for cardiovascular disease

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Defective Lymphoid Development in Mice Lacking Jak3

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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

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Senescent cells: an emerging target for diseases of ageing

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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

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Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan

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